ArticleJournal of clinical microbiology2014
Genetic diversity and antimicrobial susceptibility of Campylobacter jejuni isolates associated with sheep abortion in the United States and Great Britain.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Pathological, immunohistochemical and molecular studies onVeterinary research forum : an international quarterly journal · 2026Article
- First-ever ASM Global Research Symposium on Microbes in Human Health in Tsinghua, Beijing, China.mSphere · 2025Article
- Analysis of the sheep (Ovis aries) vaginal microbiota preceding spontaneous abortion: a pilot study.Access microbiology · 2025Article
- A Decade of Antimicrobial Resistance in Human and AnimalAntibiotics (Basel, Switzerland) · 2024Review
- Multilocus sequence typing database forMicrobiology spectrum · 2024Article
- Quadruplex qPCR for detection and discrimination of C. Coli,C. fetus, and C. Jejuni from other Campylobacter species in chicken and sheep meat.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Detection ofVeterinary world · 2024Article
- Comparative Analysis ofPathogens (Basel, Switzerland) · 2023Article
- Whole genome characterization of thermophilicFrontiers in microbiology · 2023Article
- Infectious abortions in small domestic ruminants in the Iberian Peninsula: Optimization of sampling procedures for molecular diagnostics.Frontiers in veterinary science · 2023Article
- Pharmacokinetics of tulathromycin in pregnant ewes (Ovis aries) challenged with Campylobacter jejuni.PloS one · 2021Article
- Genomic Analysis and Antimicrobial Resistance ofFrontiers in microbiology · 2021Article
- New and alternative strategies for the prevention, control, and treatment of antibiotic-resistant Campylobacter.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Antimicrobial resistance patterns and molecular resistance markers of Campylobacter jejuni isolates from human diarrheal cases.PloS one · 2020Article
- High Prevalence of Fluoroquinolone-ResistantApplied and environmental microbiology · 2019Article
- Genetic Basis and Clonal Population Structure of Antibiotic Resistance inFrontiers in microbiology · 2018Article
- Wide but Variable Distribution of a Hypervirulent Campylobacter jejuni Clone in Beef and Dairy Cattle in the United States.Applied and environmental microbiology · 2017Article
- Key Role of Capsular Polysaccharide in the Induction of Systemic Infection and Abortion by Hypervirulent Campylobacter jejuni.Infection and immunity · 2017Article
- Antimicrobial Susceptibility Profiles of Human Campylobacter jejuni Isolates and Association with Phylogenetic Lineages.Frontiers in microbiology · 2016Article
- High genetic similarity of ciprofloxacin-resistant Campylobacter jejuni in central Europe.Frontiers in microbiology · 2015Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Campylobacter infection is a leading cause of ovine abortion worldwide. Historically, genetically diverse Campylobacter fetus and Campylobacter jejuni strains have been implicated in such infections, but since 2003 a highly pathogenic, tetracycline-resistant C. jejuni clone (named SA) has become the predominant cause of sheep abortions in the United States. Whether clone SA was present in earlier U.S. abortion isolates (before 2000) and is associated with sheep abortions outside the United States are unknown. Here, we analyzed 54 C. jejuni isolates collected from U.S. sheep abortions at different time periods and compared them with 42 C. jejuni isolates associated with sheep abortion during 2002 to 2008 in Great Britain, using multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE), and array-based comparative genomic hybridization (CGH). Although clone SA (ST-8) was present in the early U.S. isolates, it was not as tetracycline resistant (19% versus 100%) or predominant (66% versus 91%) as it was in the late U.S isolates. In contrast, C. jejuni isolates from Great Britain were genetically diverse, comprising 19 STs and lacking ST-8. PFGE and CGH analyses of representative strains further confirmed the population structure of the abortion isolates. Notably, the Great Britain isolates were essentially susceptible to most tested antibiotics, including tetracycline, while the late U.S. isolates were universally resistant to this antibiotic, which could be explained by the common use of tetracyclines for control of sheep abortions in the United States but not in Great Britain. These results suggest that the dominance of clone SA in sheep abortions is unique to the United States, and the use of tetracyclines may have facilitated selection of this highly pathogenic clone.
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