ArticleMagnetic resonance in medicine2015
Rapid and accurate T2 mapping from multi-spin-echo data using Bloch-simulation-based reconstruction.
Article in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07759895 (Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in Schizophrenia), which is not on this map. Cited by 99 papers.
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Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in Schizophrenia
Who cites it
99 citing papers in PubMed.
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39 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
purposeQuantitative T2 -relaxation-based contrast has the potential to provide valuable clinical information. Practical T2 -mapping, however, is impaired either by prohibitively long acquisition times or by contamination of fast multiecho protocols by stimulated and indirect echoes. This work presents a novel postprocessing approach aiming to overcome the common penalties associated with multiecho protocols, and enabling rapid and accurate mapping of T2 relaxation values.
methodsBloch simulations are used to estimate the actual echo-modulation curve (EMC) in a multi-spin-echo experiment. Simulations are repeated for a range of T2 values and transmit field scales, yielding a database of simulated EMCs, which is then used to identify the T2 value whose EMC most closely matches the experimentally measured data at each voxel.
resultsT2 maps of both phantom and in vivo scans were successfully reconstructed, closely matching maps produced from single spin-echo data. Results were consistent over the physiological range of T2 values and across different experimental settings.
conclusionThe proposed technique allows accurate T2 mapping in clinically feasible scan times, free of user- and scanner-dependent variations, while providing a comprehensive framework that can be extended to model other parameters (e.g., T1 , B1 (+) , B0 , diffusion) and support arbitrary acquisition schemes.
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