ArticleJournal of clinical laboratory analysis2014
Performance evaluation of platelet counting by novel fluorescent dye staining in the XN-series automated hematology analyzers.
Article in Journal of clinical laboratory analysis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- Platelet-Mimicking RBC Microfragments: PLT-F Interference on Sysmex XN Analyzers in Pediatrics.International journal of laboratory hematology · 2026Article
- Automated cell count for blood component quality control.Transfusion · 2026Article
- Red Blood Cell Fragmentation Mimicking Platelet Recovery in a Patient With Severe Pneumonia.Clinical case reports · 2026Article
- Cryoglobulinemia concurrent with Leishmania infantum infection in a dog and its interference with two automated hematology analyzers.Veterinary clinical pathology · 2025Article
- Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition.International journal of hematology · 2024Article
- Stability over time of immature platelet fraction and comparison between EDTA and citrated whole blood samples.Journal of clinical laboratory analysis · 2023Article
- Comparison of platelet count results on the Sysmex XN between citrate or MgSOInternational journal of laboratory hematology · 2023Article
- Alinity hq platelet count is not impacted by severe microcytosis.Journal of clinical laboratory analysis · 2022Article
- Evaluation of automated hematology analyzer DYMIND DH76 compared to SYSMEX XN 1000 system.Journal of medical biochemistry · 2021Article
- Use of Middleware Data to Dissect and Optimize Hematology Autoverification.Journal of pathology informatics · 2021Article
- Effects of Time-Interval since Blood Draw and of Anticoagulation on Platelet Testing (Count, Indices and Impedance Aggregometry): A Systematic Study with Blood from Healthy Volunteers.Journal of clinical medicine · 2020Article
- Changes in novel haematological parameters following thermal injury: A prospective observational cohort study.Scientific reports · 2017Observational
- Sample stability for complete blood cell count using the Sysmex XN haematological analyser.Blood transfusion = Trasfusione del sangue · 2015Article
- Clinical significance of IPF% or RP% measurement in distinguishing primary immune thrombocytopenia from aplastic thrombocytopenic disorders.International journal of hematology · 2015Article
- Accuracy of a New Platelet Count System (PLT-F) Depends on the Staining Property of Its Reagents.PloS one · 2015Article
- Assessment of blood sample stability for complete blood count using the Sysmex XN-9000 and Mindray BC-6800 analyzers.Revista brasileira de hematologia e hemoterapiaArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConventional automated hematology analyzers have limitations in platelet measurements such as poor accuracy and precision in the low count range and interference by nonplatelet particles. In order to improve it, the newly developed XN-Series automated hematology analyzers (Sysmex Corporation, Kobe, Japan) have been installed with a new dedicated channel for platelet analysis (PLT-F), which is based on a fluorescence flow cytometry method with uses of a novel fluorescent dye specifically staining platelets. We evaluated the basic performance of this new PLT-F channel.
methodsBasic performance of the PLT-F channel in within-run reproducibility and assay linearity was studied using standard methods. Correlation was studied between PLT-F and a conventional automated hematology analyzer (XE-2100) and immunoplatelet analysis using anti-CD61 monoclonal antibody (Cell-Dyn Sapphire; Abbott Laboratories). The assay interference by nonplatelet particles such as fragmented red and white blood cells was evaluated by using clinical samples, respectively, from burn injury and acute leukemia.
resultsBasic performance of the PLT-F platelet counting was satisfactory in within-run reproducibility, linearity and correlation with the conventional analyzer. The correlation was satisfactory also with the immunoplatelet analysis, even for samples from a patient with burn injury, and those with white blood cell fragments displayed, platelet abnormal flag and low platelet counts (<50 × 10(9)/l).
conclusionThe platelet counting performance of the PLT-F channel of the XN Series had improved accuracy and precision in the low range and in abnormal samples, avoiding the interference by nonplatelet particles.
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