ArticleEuropean journal of clinical pharmacology2014
Potentially inappropriate prescribing in elderly outpatients in Croatia.
Article in European journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Prevalence of Drug-Drug Interactions in Older Community-Dwelling Individuals: A Systematic Review and Meta-analysis.Drugs & aging · 2023 · on this mapPooled it
- Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta-analysis.Scientific reports · 2022Pooled it
- Brief interventions targeting long-term benzodiazepine and Z-drug use in primary care: a systematic review and meta-analysis.Addiction (Abingdon, England) · 2020Pooled it
- Prevalence of statin-drug interactions in older people: a systematic review.European journal of clinical pharmacology · 2016Pooled it
- Potentially inappropriate prescribing in community-dwelling older people across Europe: a systematic literature review.European journal of clinical pharmacology · 2015Pooled it
- Tailoring an Implementation Strategy for Deprescribing as Part of a Comprehensive Geriatric Assessment (dCGA) in Long-Term Care Facilities: A Roundtable Discussion.Basic & clinical pharmacology & toxicology · 2026Article
- Assessing potentially inappropriate medication use among older adults in Central and Eastern Europe.Annals of medicine · 2025Article
- Screening criteria of potentially inappropriate medications and associations of exposure timing with incident hospital admissions among older adults in a rural community hospital.BMC geriatrics · 2025Article
- The (Mis)use of Psychotropic Drugs and Addiction to Anxiolytics among Older Adults Living at Home or in Retirement Homes: Implications for Quality of Life.Healthcare (Basel, Switzerland) · 2023Article
- Review
- Potentially Inappropriate Prescribing and Potential Clinically Significant Drug-Drug Interactions in Older Outpatients: Is There Any Association?Medicina (Kaunas, Lithuania) · 2019Article
- Medication use in older patients and age-blind approach: narrative literature review (insufficient evidence on the efficacy and safety of drugs in older age, frequent use of PIMs and polypharmacy, and underuse of highly beneficial nonpharmacological strategies).European journal of clinical pharmacology · 2019Review
- Potentially inappropriate medicines in elderly hospitalised patients according to the EU(7)-PIM list, STOPP version 2 criteria and comprehensive protocol.European journal of clinical pharmacology · 2017Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to determine the prevalence of inappropriate prescribing to the elderly and to identify possible gender-related differences in prescribing certain potentially inappropriate medications (PIMs) to outpatients by using large administrative prescription database.
methodsMedications prescribed for elderly outpatients (≥ 65 years) in Primorsko-Goranska County, Croatia, who received five or more different drugs simultaneously in 2010, were analyzed. The prevalence of potentially inappropriate drugs prescribed to the elderly was assessed using the new comprehensive protocol developed by authors Mimica Matanović and Vlahović-Palčevski.
resultsA total of 62.4 % of patients received at least one medication with unfavorable benefit/risk ratio in the elderly. Female patients were given inappropriate medications in a significantly higher percentage than men (69.3 % vs. 50.5 %; p < 0.001). The average number of prescriptions for PIMs that should have been avoided with certain diseases or conditions was 0.88 per patient in the survey. The most common drug combination potentially leading to serious drug-drug interactions (DDIs) included an angiotensin-converting enzyme (ACE) inhibitor and a potassium supplement.
conclusionsOur study has shown that every tenth medication prescribed to a patient > 65 years and receiving five or more drugs was potentially inappropriate. Elderly women were prescribed PIMs more often than men. Drugs of concern in female patients were benzodiazepines, antidepressants, and nonsteroidal anti-inflammatory drugs (NSAIDs). In male patients, there was a significantly higher proportion of possible interactions with warfarin, theophylline, and medications affecting the cardiovascular system, such as ACE inhibitors and amiodarone.
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