ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Postnatal maturation of the red nucleus motor map depends on rubrospinal connections with forelimb motor pools.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 40 citations in OpenAlex.
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- Differential participation of the corticospinal and corticorubral neurons during motor execution in the rat.Scientific reports · 2025Article
- More Than a Small Brain: The Importance of Studying Neural Function during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
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- Heterogeneous Diffusion Metrics Patterns in Delayed Encephalopathy After Acute Carbon Monoxide Poisoning: A Case Report.Brain & NeuroRehabilitation · 2023Article
- Spinal cord representation of motor cortex plasticity reflects corticospinal tract LTP.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Sustained interleukin-10 delivery reduces inflammation and improves motor function after spinal cord injury.Journal of neuroinflammation · 2019Article
- Altered brain iron content and deposition rate in Huntington's disease as indicated by quantitative susceptibility MRI.Journal of neuroscience research · 2019Article
- Differences in neuroplasticity after spinal cord injury in varying animal models and humans.Neural regeneration research · 2019Review
- Article
- Repair after brainstem ischemia involves neurogenesis and the rubrospinal system.Annals of neurology · 2018Article
- Motor system plasticity after unilateral injury in the developing brain.Developmental medicine and child neurology · 2017Review
- Theta Oscillations during Active Sleep Synchronize the Developing Rubro-Hippocampal Sensorimotor Network.Current biology : CB · 2017Article
- Focal Stroke in the Developing Rat Motor Cortex Induces Age- and Experience-Dependent Maladaptive Plasticity of Corticospinal System.Frontiers in neural circuits · 2017Article
- A new view of "dream enactment" in REM sleep behavior disorder.Sleep medicine reviews · 2016Review
- Spontaneous activity and functional connectivity in the developing cerebellorubral system.Journal of neurophysiology · 2016Article
- Awake behaving electrophysiological correlates of forelimb hyperreflexia, weakness and disrupted muscular synchronization following cervical spinal cord injury in the rat.Behavioural brain research · 2016Article
- Reorganization of Intact Descending Motor Circuits to Replace Lost Connections After Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
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Abstract
The red nucleus (RN) and rubrospinal tract (RST) are important for forelimb motor control. Although the RST is present postnatally in cats, nothing is known about when rubrospinal projections could support motor functions or the relation between the development of the motor functions of the rubrospinal system and the corticospinal system, the other major system for limb control. Our hypothesis is that the RN motor map is present earlier in development than the motor cortex (M1) map, to support early forelimb control. We investigated RN motor map maturation with microstimulation and RST cervical enlargement projections using anterograde tracers between postnatal week 3 (PW3) and PW16. Microstimulation and tracer injection sites were verified histologically to be located within the RN. Microstimulation at PW4 evoked contralateral wrist, elbow, and shoulder movements. The number of sites producing limb movement increased and response thresholds decreased progressively through PW16. From the outset, all forelimb joints were represented. At PW3, RST projections were present within the cervical intermediate zone, with a mature density of putative synapses. In contrast, beginning at PW5 there was delayed and age-dependent development of forelimb motor pool projections and putative rubromotoneuronal synapses. The RN has a more complete forelimb map early in development than previous studies showed for M1, supporting our hypothesis of preferential rubrospinal rather than corticospinal control for early movements. Remarkably, development of the motor pool, not intermediate zone, RST projections paralleled RN motor map development. The RST may be critical for establishing the rudiments of motor skills that subsequently become refined with further CST development.
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