ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Cortical neuron response properties are related to lesion extent and behavioral recovery after sensory loss from spinal cord injury in monkeys.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Characterizing Evoked Movement Patterns and Connectivity in Sensorimotor Cortex After Sensory Loss in Squirrel Monkeys.The Journal of comparative neurology · 2025Article
- Longitudinal fMRI measures of cortical reactivation and hand use with and without training after sensory loss in primates.NeuroImage · 2021Article
- Intensity of Intraoperative Spinal Cord Hyperechogenicity as a Novel Potential Predictive Indicator of Neurological Recovery for Degenerative Cervical Myelopathy.Korean journal of radiology · 2021Article
- Corticocuneate projections are altered after spinal cord dorsal column lesions in New World monkeys.The Journal of comparative neurology · 2021Article
- Reorganization of Higher-Order Somatosensory Cortex After Sensory Loss from Hand in Squirrel Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Width and neurophysiologic properties of tissue bridges predict recovery after cervical injury.Neurology · 2019Article
- Differences in neuroplasticity after spinal cord injury in varying animal models and humans.Neural regeneration research · 2019Review
- Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury.Nature communications · 2018Article
- Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys.Scientific reports · 2018Article
- Second-order spinal cord pathway contributes to cortical responses after long recoveries from dorsal column injury in squirrel monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Spatiotemporal trajectories of reactivation of somatosensory cortex by direct and secondary pathways after dorsal column lesions in squirrel monkeys.NeuroImage · 2016Article
- Intracortical connections are altered after long-standing deprivation of dorsal column inputs in the hand region of area 3b in squirrel monkeys.The Journal of comparative neurology · 2016Article
- Chronic recordings reveal tactile stimuli can suppress spontaneous activity of neurons in somatosensory cortex of awake and anesthetized primates.Journal of neurophysiology · 2016Article
- Plasticity and Recovery After Dorsal Column Spinal Cord Injury in Nonhuman Primates.Journal of experimental neuroscience · 2016Review
- Congenital foot deformation alters the topographic organization in the primate somatosensory system.Brain structure & function · 2016Article
- Spinal cord neuron inputs to the cuneate nucleus that partially survive dorsal column lesions: A pathway that could contribute to recovery after spinal cord injury.The Journal of comparative neurology · 2015Article
- Cortical reorganization after spinal cord injury: always for good?Neuroscience · 2014Review
- The reactivation of somatosensory cortex and behavioral recovery after sensory loss in mature primates.Frontiers in systems neuroscience · 2014Review
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5 authors.
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Abstract
Lesions of the dorsal columns at a mid-cervical level render the hand representation of the contralateral primary somatosensory cortex (area 3b) unresponsive. Over weeks of recovery, most of this cortex becomes responsive to touch on the hand. Determining functional properties of neurons within the hand representation is critical to understanding the neural basis of this adaptive plasticity. Here, we recorded neural activity across the hand representation of area 3b with a 100-electrode array and compared results from owl monkeys and squirrel monkeys 5-10 weeks after lesions with controls. Even after extensive lesions, performance on reach-to-grasp tasks returned to prelesion levels, and hand touches activated territories mainly within expected cortical locations. However, some digit representations were abnormal, such that receptive fields of presumably reactivated neurons were larger and more often involved discontinuous parts of the hand compared with controls. Hand stimulation evoked similar neuronal firing rates in lesion and control monkeys. By assessing the same monkeys with multiple measures, we determined that properties of neurons in area 3b were highly correlated with both the lesion severity and the impairment of hand use. We propose that the reactivation of neurons with near-normal response properties and the recovery of near-normal somatotopy likely supported the recovery of hand use. Given the near-completeness of the more extensive dorsal column lesions we studied, we suggest that alternate spinal afferents, in addition to the few spared primary axon afferents in the dorsal columns, likely have a major role in the reactivation pattern and return of function.
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