SynthesisMedical oncology (Northwood, London, England)2014
Therapeutic vaccination for non-small-cell lung cancer: a meta-analysis.
Synthesis in Medical oncology (Northwood, London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Therapeutic vaccines for advanced non-small cell lung cancer.The Cochrane database of systematic reviews · 2024Pooled it
- Evaluation of clinical and safety outcomes of cancer vaccines in patients with advanced non-small cell lung cancer after first-line therapy: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung cancer is the most common malignancy worldwide in terms of incidence and mortality. The vast majority of cases (85-90%) are non-small-cell lung cancer (NSCLC). Immunotherapy consists of mainly therapeutic vaccination designed to induce or amplify the immune responses directed against tumor-associated antigens. However, there is no conclusion to date for its strengths and weaknesses. Assessing the objective efficacy and safety of the therapeutic vaccination for NSCLC patients will help to figure out the future development of therapeutic vaccination. We performed a meta-analysis of six randomized controlled trials including 2,239 patients (1,363 patients in the therapeutic vaccination group and 876 patients in the control group) with NSCLC. Quantitative analysis was carried out to evaluate overall survival (OS) and toxicity of therapeutic vaccination. The vaccine group had produced significant improvement in OS compared with the control group [hazard ratio (HR) 0.83, 95% (confidence interval) CI 0.76-0.91; Z = 3.79, P = 0.0002]. Subgroup analysis showed a more significant improvement of OS in the subgroup compared with the control group (HR 0.70, 95% CI 0.59-0.82; Z = 4.42, P < 0.00001). No increased incidence of adverse events was obtained in the therapeutic vaccination group compared with the control group. Therapeutic vaccination adds benefits to NSCLC patients and may become a standard complementary therapeutic approach in the future if the associated toxicity is reduced.
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Registered trials
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