SynthesisDiabetes2014
Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Diabetes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 8 pooled it
4.7field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 8 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Association between type 2 diabetes and amyotrophic lateral sclerosis.Scientific reports · 2022Pooled it
- Pooled it
- Gene-diet interaction effects on BMI levels in the Singapore Chinese population.Nutrition journal · 2018Pooled it
- Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6-TMC8 and SIX3-SIX2 loci associated with HbAScientific reports · 2017Pooled it
- Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.PLoS medicine · 2017Pooled it
- Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.American journal of human genetics · 2017Pooled it
- Meta-analyses of the association of G6PC2 allele variants with elevated fasting glucose and type 2 diabetes.PloS one · 2017Pooled it
- Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis.Diabetologia · 2015Pooled it
- Article
- Relationships between glucose variability with white matter hyperintensity and cerebrovascular abnormalities.Archives of endocrinology and metabolism · 2026Article
- Visit-to-visit glucose variability is associated with echocardiographic variables in people with type 2 diabetes: epidemiological and mendelian randomization approaches.Diabetology & metabolic syndrome · 2025Article
- Hemoglobin A1c Genetics and Disparities in Risk of Diabetic Retinopathy in Individuals of Genetically Inferred African American/African British and European Ancestries.Diabetes care · 2024Article
- Glycemic traits and colorectal cancer survival in a cohort of South Korean patients: A Mendelian randomization analysis.Cancer medicine · 2024Article
- Ethnicity Affects A1C Levels in Patients With Diagnosed Type 2 Diabetes in Southern Israel.Diabetes spectrum : a publication of the American Diabetes Association · 2024Article
- Causal link between metabolic related factors and osteoarthritis: a Mendelian randomization investigation.Frontiers in nutrition · 2024Article
- Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population.Diabetology international · 2023Article
- Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Correlation between diabetic retinopathy and diabetic nephropathy: a two-sample Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Birth weight is associated with obesity and T2DM in adulthood among Chinese women.BMC endocrine disorders · 2022Article
- A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.Nature genetics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
71 authors at 20 institutions in 8 countries.
Peng ChenSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Fumihiko TakeuchiNational Center for Global Health and Medicine, Tokyo, Japan.
Jong-Young LeeCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Huaixing LiKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Jer-Yuarn WuInstitute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanSchool of Chinese Medicine, China Medical University, Taichung, Taiwan.
Jun LiangDepartment of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China.
Jirong LongVanderbilt Epidemiology Center and Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Yasuharu TabaraCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan.
Mark O GoodarziDivision of Endocrinology, Diabetes, and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA.
Mark A PereiraDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Young Jin KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Min Jin GoCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Daniel O StramDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Eranga VithanaSingapore Eye Research Institute, Singapore National Eye Centre, SingaporeNeuroscience and Behavioural Disorders (NBD) Program, Duke-National University of Singapore Graduate Medical School, Singapore.
Chiea-Chuen KhorSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, SingaporeDepartment of Ophthalmology, National University of Singapore, SingaporeGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, SingaporeDepartment of Paediatrics, National University of Singapore, Singapore.
Jianjun LiuSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, SingaporeGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Jiemin LiaoSingapore Eye Research Institute, Singapore National Eye Centre, SingaporeDepartment of Ophthalmology, National University of Singapore, Singapore.
Xingwang YeKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Yiqin WangKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Ling LuKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Terri L YoungNeuroscience and Behavioural Disorders (NBD) Program, Duke-National University of Singapore Graduate Medical School, SingaporeDuke Eye Center, Duke University Medical Center, Durham, NC.
Jeannette LeeSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Ah Chuan ThaiDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ching-Yu ChengSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, SingaporeDepartment of Ophthalmology, National University of Singapore, SingaporeCentre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of Singapore Graduate Medical School, Singapore.
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Yechiel FriedlanderHebrew University, School of Public Health, Jerusalem, Israel.
Chew-Kiat HengDepartment of Paediatrics, National University of Singapore, Singapore.
Woon-Puay KohSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, SingaporeDuke-National University of Singapore Graduate Medical School, Singapore.
Chien-Hsiun ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanSchool of Chinese Medicine, China Medical University, Taichung, Taiwan.
Li-Ching ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Wen-Harn PanInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Masato IsonoNational Center for Global Health and Medicine, Tokyo, Japan.
Wei ZhengVanderbilt Epidemiology Center and Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Qiuyin CaiVanderbilt Epidemiology Center and Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Yutang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Ken YamamotoDivision of Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Keizo OhnakaDepartment of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ryoichi TakayanagiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yoshikuni KitaDepartment of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Japan.
Hirotsugu UeshimaDepartment of Health Science, and Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Japan.
Chao A HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Jinrui CuiDivision of Endocrinology, Diabetes, and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA.
Wayne H-H SheuDivision of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanSchool of Medicine, National Defense Medical Center, Taipei, Taiwan.
Jerome I RotterInstitute for Translational Genomics and Biomedical Sciences, Los Angeles Biomedical Research Institute, Harbor-University of California, Los Angeles Medical Center, Torrance, CA.
Yii-Der I ChenInstitute for Translational Genomics and Biomedical Sciences, Los Angeles Biomedical Research Institute, Harbor-University of California, Los Angeles Medical Center, Torrance, CA.
Chris HsuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Yukinori OkadaDepartment of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Michiaki KuboLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Toshihiro TanakaDepartment of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanLaboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Frank J A van RooijDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Santhi K GaneshDepartments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI.
Jinyan HuangDepartment of Epidemiology, Harvard School of Public Health, Boston, MA.
Tao HuangDepartment of Epidemiology, Harvard School of Public Health, Boston, MA.
Jianmin YuanUniversity of Pittsburgh Cancer Institute, Pittsburgh, PA.
Joo-Yeon HwangCenter for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
CHARGE Hematology Working Group
Myron D GrossDepartment of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA.
Tetsuro MikiDepartment of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Xiao-Ou ShuVanderbilt Epidemiology Center and Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Lu QiDepartment of Nutrition, Harvard School of Public Health, Boston, MAChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Yuan-Tson ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanDepartment of Pediatrics, Duke University Medical Center, Durham, NC.
Xu LinKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Tin AungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Tien-Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, SingaporeDepartment of Ophthalmology, National University of Singapore, Singapore.
Yik-Ying TeoSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, SingaporeGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, SingaporeNUS Graduate School for Integrative Science and Engineering, National University of Singapore, SingaporeDepartment of Statistics and Applied Probability, National University of Singapore, Singapore.
Bong-Jo KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Norihiro KatoNational Center for Global Health and Medicine, Tokyo, Japan.
E-Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeDuke-National University of Singapore Graduate Medical School, Singapore e_shyong_tai@nuhs.edu.sg.
National University of Singapore · SGChinese Academy of Sciences · CNAgency for Science, Technology and Research · SGVanderbilt University · USKorea National Institute of Health · KRKyushu University · JPNational Center for Global Health and Medicine · JPThe Lundquist Institute · USBrigham and Women's Hospital · USCedars-Sinai Medical Center · USChina Medical University · TWHarvard University · USInstitute of Biomedical Sciences, Academia Sinica · TWRIKEN Center for Integrative Medical Sciences · JPShiga University of Medical Science · JPTokyo Medical and Dental University · JPUniversity of Minnesota Medical Center · USUniversity of Southern California · USAlbert Einstein College of Medicine · USEhime University · JP
Funding
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MShanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9MNCATS NIH HHS UL1 TR000124NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182910NHLBI NIH HHS R01 HL105756NIDDK NIH HHS P30 DK063491
Abstract
Glycated hemoglobin A1c (HbA1c) is used as a measure of glycemic control and also as a diagnostic criterion for diabetes. To discover novel loci harboring common variants associated with HbA1c in East Asians, we conducted a meta-analysis of 13 genome-wide association studies (GWAS; N = 21,026). We replicated our findings in three additional studies comprising 11,576 individuals of East Asian ancestry. Ten variants showed associations that reached genome-wide significance in the discovery data set, of which nine (four novel variants at TMEM79 [P value = 1.3 × 10(-23)], HBS1L/MYB [8.5 × 10(-15)], MYO9B [9.0 × 10(-12)], and CYBA [1.1 × 10(-8)] as well as five variants at loci that had been previously identified [CDKAL1, G6PC2/ABCB11, GCK, ANK1, and FN3KI]) showed consistent evidence of association in replication data sets. These variants explained 1.76% of the variance in HbA1c. Several of these variants (TMEM79, HBS1L/MYB, CYBA, MYO9B, ANK1, and FN3K) showed no association with either blood glucose or type 2 diabetes. Among individuals with nondiabetic levels of fasting glucose (<7.0 mmol/L) but elevated HbA1c (≥6.5%), 36.1% had HbA1c <6.5% after adjustment for these six variants. Our East Asian GWAS meta-analysis has identified novel variants associated with HbA1c as well as demonstrated that the effects of known variants are largely transferable across ethnic groups. Variants affecting erythrocyte parameters rather than glucose metabolism may be relevant to the use of HbA1c for diagnosing diabetes in these populations.
Indexed as
Genetic LociAdultAgedAsia, EasternAsian PeopleBlood GlucoseCohort StudiesFemaleGenetic HeterogeneityGenome-Wide Association StudyGlycated HemoglobinHumansMaleMiddle AgedPolymorphism, Single NucleotideBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, human
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