Evidence map›Paper›PMID 24647631›Full record

ArticlePloS one2014

Prox1 and FOXC2 act as regulators of lymphangiogenesis and angiogenesis in oral squamous cell carcinoma.

Tomonori Sasahira, Nobuhiro Ueda, Kazuhiko Yamamoto, Miyako Kurihara, Sayako Matsushima, Ujjal K Bhawal, Tadaaki Kirita, Hiroki Kuniyasu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Meta-analysis of the prognostic significance of FOXC2 in various tumors.The Journal of international medical research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tomonori SasahiraDepartment of Molecular Pathology, Nara Medical University, Kashihara, Japan.
Nobuhiro UedaDepartment of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Japan.
Kazuhiko YamamotoDepartment of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Japan.
Miyako KuriharaDepartment of Molecular Pathology, Nara Medical University, Kashihara, Japan; Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Japan.
Sayako MatsushimaDepartment of Molecular Pathology, Nara Medical University, Kashihara, Japan.
Ujjal K BhawalDepartment of Molecular Pathology, Nara Medical University, Kashihara, Japan; Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo, Matsudo, Japan.
Tadaaki KiritaDepartment of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Japan.
Hiroki KuniyasuDepartment of Molecular Pathology, Nara Medical University, Kashihara, Japan.
Nara Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prospero homeobox 1 (Prox1) and forkhead box (FOX) C2 regulate angiogenesis and/or lymphangiogenesis. However, the detailed role and function of Prox1 and FOXC2 in cancer remains controversial. In the present study, we examined the expression of Prox1 and FOXC2 proteins in specimens from 163 cases with oral squamous cell carcinoma (OSCC). Furthermore, the role of Prox1 and FOXC2 in cancer cell growth and invasion was evaluated in cultured OSCC cells. Prox1 expression was significantly associated with local progression of the tumor (P = 0.0023), clinical stage (P<0.0001), lymphovessel density (LVD) (P<0.0001), nodal metastasis (P<0.0001), and worse prognosis (P<0.0001). Immunoreactivity of FOXC2 was strongly correlated with microvessel density (MVD) (P<0.0001) and poor prognosis (P = 0.0076). In vitro analysis demonstrated that Prox1 regulates cell growth, proliferation, invasion, and lymphangiogenesis by activating vascular endothelial growth factor (VEGF)-C expression. Furthermore, FOXC2 enhanced the expression level of Prox1 and promoted angiogenesis by enhancement of VEGF-A expression. Our results suggested that Prox1 and FOXC2 play key roles in OSCC progression and that further studies focusing on these proteins may yield useful insights for diagnosis and therapy of OSCC.

Indexed as

AdultAgedAged, 80 and overCarcinoma, Squamous CellCell Line, TumorFemaleForkhead Transcription FactorsHomeodomain ProteinsHumansIn Vitro TechniquesLymphangiogenesisMaleMiddle AgedNeovascularization, PathologicProspero-Related Homeobox 1 ProteinTumor Suppressor ProteinsForkhead Transcription FactorsHomeodomain Proteinsmesenchyme fork head 1 proteinProspero-Related Homeobox 1 ProteinTumor Suppressor Proteins

Identifiers

PMID24647631
PMCPMC3960274
OpenAlexW1980802319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.