ArticleEuropean archives of psychiatry and clinical neuroscience2014
Putting things into perspective: the nature and impact of theory of mind impairment in Huntington's disease.
Article in European archives of psychiatry and clinical neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Quality of life, health-related quality of life, and associated factors in Huntington's disease: a systematic review.Journal of neurology · 2023Pooled it
- A 20-Year Systematic Review of the 'Reading the Mind in the Eyes' Test across Neurodegenerative Conditions.Brain sciences · 2023Review
- The non-human animal reading the mind in the eyes test (NARMET): A new measure for the assessment of social cognition.Frontiers in psychiatry · 2023Article
- Social cognition and quality of life in Huntington's disease.Frontiers in psychiatry · 2022Article
- Exploring Influences on Theory of Mind Impairment in Opioid Dependent Patients.Frontiers in psychiatry · 2021Article
- Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach.Neuropsychiatric disease and treatment · 2019Review
- What Do You Have in Mind? Measures to Assess Mental State Reasoning in Neuropsychiatric Populations.Frontiers in psychiatry · 2019Review
- Through your eyes or mine? The neural correlates of mental state recognition in Huntington's disease.Human brain mapping · 2018Article
- Theory of Mind Is Impaired in Mild to Moderate Huntington's Disease Independently from Global Cognitive Functioning.Frontiers in psychology · 2017Article
- From movement kinematics to social cognition: the case of autism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Interaction without intent: the shape of the social world in Huntington's disease.Social cognitive and affective neuroscience · 2015Article
- The role of the amygdala during emotional processing in Huntington's disease: from pre-manifest to late stage disease.Neuropsychologia · 2015Article
- New aspects of cognition domains and psychopathological measures in psychiatry.European archives of psychiatry and clinical neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Huntington's disease (HD), frontostriatal dysfunction may lead to deficits in theory of mind (ToM), in addition to broader cognitive impairment. We investigated relationships between patients' spatial and social perspective taking performance and executive deficits, self-reported everyday perspective taking, motor symptoms, functional capacity and quality of life. Thirty patients with symptomatic HD and twenty-three healthy controls of similar age and education completed two ToM tasks, a scale assessing everyday interpersonal perspective taking, a novel object-based spatial perspective taking task (SPT) and executive measures. Ratings of quality of life, psychiatric symptoms, motor symptom severity and functional capacity were also taken for patients. When compared to controls, patients exhibited significant deficits in ToM and spatial perspective taking and lower everyday perspective taking scores. Executive deficits were linked to poor understanding of socially inappropriate remarks and errors in mental state attribution. This may be the first study to show that aspects of ToM performance are linked to spatial perspective taking, motor symptom severity and functional capacity in HD. Our findings indicate that patients with HD exhibit evidence of reduced perspective taking in everyday life in addition to poor performance on social and SPTs. They also emphasise the need to better specify the precise cognitive and neural bases for ToM deficits in neurodegenerative conditions. Further research exploring the impact of striatal degeneration on perspective taking abilities will make a valuable contribution to the continued development of functional models of frontostriatal circuitry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.