ArticlePloS one2014
Transcriptome analyses of the honeybee response to Nosema ceranae and insecticides.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
93 citing papers in PubMed, 3 syntheses or guidelines pooled it, 222 citations in OpenAlex.
- Meta-Analysis and Experimental Evidence Reveal No Impact of Nosema ceranae Infection on Honeybee Carbohydrate Consumption.Microbial ecology · 2025Pooled it
- Nosemosis negatively affects honeybee survival: experimental and meta-analytic evidence.Parasitology · 2024Pooled it
- A systematic review of honey bee (Apis mellifera, Linnaeus, 1758) infections and available treatment options.Veterinary medicine and science · 2023Pooled it
- Pilot Study of Grape Pomace Extract Impact onInsects · 2026Article
- Differential expression of neuronal function genes follows a tissue-specific temporal dynamic during Deformed Wing Virus infection in honeybees.Scientific reports · 2026Article
- Unraveling pesticide impacts on pollinators: a global challenge for sustainable crop protection.Die Naturwissenschaften · 2026Review
- What's in a pollen provision? Using larval provisions to quantify pesticide exposure in Megachile rotundata (Hymenoptera: Megachilidae).Environmental entomology · 2026Article
- Article
- Interactions between ionizing radiation and Vairimorpha (Nosema) ceranae on the honeybee, Apis mellifera L.PloS one · 2026Article
- Gene Expression Associated With Behaviour Manipulation in Wood Ants Infected With Larval Lancet Fluke, Dicrocoelium dendriticum.Molecular ecology · 2025Article
- Neonicotinoids and Varroa mites force the extending of longevity in a bee colony during overwintering to forget.Scientific reports · 2025Article
- Acute and chronic pesticide exposure trigger fundamentally different molecular responses in bumble bee brains.BMC biology · 2025Article
- Co-exposure to a honeybee pathogen and an insecticide: synergistic effects in a new solitary bee host but not inProceedings. Biological sciences · 2025Article
- Impact of Sublethal Insecticides Exposure onInsects · 2024Article
- Article
- Potential of Wormwood and Oak Bark-Based Supplement in Health Improvement ofAnimals : an open access journal from MDPI · 2024Article
- Influence of Age of Infection on the Gut Microbiota in Worker Honey Bees (Microorganisms · 2024Article
- Comparative transcriptome analysis of whiteflies raised onFrontiers in veterinary science · 2024Article
- Extensive influence of microsporidian infection on sucrose solution consumption, antioxidant enzyme activity, cell structure, and lifespan of Asian honeybees.Frontiers in immunology · 2024Article
- Review
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Honeybees (Apis mellifera) are constantly exposed to a wide variety of environmental stressors such as parasites and pesticides. Among them, Nosema ceranae and neurotoxic insecticides might act in combination and lead to a higher honeybee mortality. We investigated the molecular response of honeybees exposed to N. ceranae, to insecticides (fipronil or imidacloprid), and to a combination of both stressors. Midgut transcriptional changes induced by these stressors were measured in two independent experiments combining a global RNA-Seq transcriptomic approach with the screening of the expression of selected genes by quantitative RT-PCR. Although N. ceranae-insecticide combinations induced a significant increase in honeybee mortality, we observed that they did not lead to a synergistic effect. According to gene expression profiles, chronic exposure to insecticides had no significant impact on detoxifying genes but repressed the expression of immunity-related genes. Honeybees treated with N. ceranae, alone or in combination with an insecticide, showed a strong alteration of midgut immunity together with modifications affecting cuticle coatings and trehalose metabolism. An increasing impact of treatments on gene expression profiles with time was identified suggesting an absence of stress recovery which could be linked to the higher mortality rates observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.