Evidence map›Paper›PMID 24646797›Full record

ArticleThe Journal of investigative dermatology2014

Plakophilins, desmogleins, and pemphigus: the tail wagging the dog.

Christoph T Ellebrecht, Aimee S Payne

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Changes in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study.Comparative immunology, microbiology and infectious diseases · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christoph T EllebrechtDepartment of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Aimee S PayneDepartment of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: paynea@mail.med.upenn.edu.
University of Pennsylvania · US

Funding

Role of autoantibody isotype in pemphigus pathogenesisR01AR057001 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI PAYNE, AIMEE S · 2010 to 2014
$1.7M
NIAMS NIH HHS AR057001NIAMS NIH HHS R01 AR057001
6 · The paper itself

Abstract

The importance of desmosomal cell adhesion to human health is evidenced by the autoimmune disease pemphigus vulgaris (PV), in which autoantibodies against the extracellular domain of the desmosomal cadherin desmoglein 3 cause potentially fatal blistering of the skin and mucous membranes. Tucker et al. describe how enhanced expression of a desmosomal cytoplasmic plaque protein, plakophilin-1, protects keratinocytes from PV IgG-induced loss of cell adhesion by inducing calcium-independent hyperadhesive desmosomes. This study beautifully demonstrates that desmosomal adhesion can be modulated by the molecular interactions of the desmoglein tail and suggests that these novel regulatory pathways may possibly be exploited in treating human disease.

Indexed as

CalciumDesmosomesHumansImmunoglobulin GKeratinocytesPemphigusPlakophilinsCalciumImmunoglobulin GPKP1 protein, humanPlakophilins

Identifiers

PMID24646797
PMCPMC3968779
OpenAlexW2045305806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.