ArticleJournal of immunology (Baltimore, Md. : 1950)2014
Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
52 citing papers in PubMed, 69 citations in OpenAlex.
- The Role and Research Progress of CD8Biomedicines · 2025Review
- FUNCTIONAL IMMUNOPHENOTYPING FOR PRECISION THERAPIES IN SEPSIS.Shock (Augusta, Ga.) · 2025Review
- DOCK2 protects against bacterial sepsis by constraining T helper 1 response.Frontiers in immunology · 2025Article
- Metabolic reprogramming and dysregulated IL-17 production impairs CD4 T cell function post sepsis.iScience · 2024Article
- Prognostic impacts of repeated sepsis in intensive care unit on autoimmune disease patients: a retrospective cohort study.BMC infectious diseases · 2024Article
- Sepsis leads to lasting changes in phenotype and function of naïve CD8 T cells.PLoS pathogens · 2023Article
- Sublethal whole-body irradiation induces permanent loss and dysfunction in pathogen-specific circulating memory CD8 T cell populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Inefficient Recovery of Repeatedly Stimulated Memory CD8 T Cells after Polymicrobial Sepsis Induction Leads to Changes in Memory CD8 T Cell Pool Composition.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- CD146+ Umbilical Cord Mesenchymal Stem Cells Exhibit High Immunomodulatory Activity and Therapeutic Efficacy in Septic Mice.Journal of inflammation research · 2023Article
- Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets.Frontiers in immunology · 2023Review
- Article
- Advances in Immune Monitoring Approaches for Sepsis-Induced Immunosuppression.Frontiers in immunology · 2022Review
- Study on the protective effect of berberine treatment on sepsis based on gut microbiota and metabolomic analysis.Frontiers in nutrition · 2022Article
- TLR2-induced CD8Frontiers in immunology · 2022Article
- Autoimmunity Increases Susceptibility to and Mortality from Sepsis.ImmunoHorizons · 2021Article
- Article
- Severity of Sepsis Determines the Degree of Impairment Observed in Circulatory and Tissue-Resident Memory CD8 T Cell Populations.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Prolonged Reactive Oxygen Species Production following Septic Insult.ImmunoHorizons · 2021Observational
- The IL-27 receptor regulates TIGIT on memory CD4iScience · 2021Article
- Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells.eLife · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Mortality from sepsis frequently results from secondary infections, and the extent to which sepsis affects pathogen-specific memory CD8 T cell responses remains unknown. Using the cecal ligation and puncture model of polymicrobial sepsis, we observed rapid apoptosis of pre-existing memory CD8 T cells after sepsis induction that led to a loss in CD8 T cell-mediated protection. Ag sensitivity (functional avidity) and Ag-driven secondary expansion of memory CD8 T cells were decreased after sepsis, further contributing to the observed loss in CD8 T cell-mediated immunity. Moreover, Ag-independent bystander activation of memory CD8 T cells in response to heterologous infection was also significantly impaired early after sepsis induction. The reduced sensitivity of pre-existing memory CD8 T cells to sense inflammation and respond to heterologous infection by IFN-γ production was observed in inbred and outbred hosts and controlled by extrinsic (but not cell-intrinsic) factors, suggesting that sepsis-induced changes in the environment regulate innate functions of memory CD8 T cells. Taken together, the data in this study revealed a previously unappreciated role of sepsis in shaping the quantity and functionality of infection- or vaccine-induced memory CD8 T cells and will help further define the decline in T cell-mediated immunity during the sepsis-induced phase of immunosuppression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.