ArticleThe ISME journal2014
Secondary metabolite gene expression and interplay of bacterial functions in a tropical freshwater cyanobacterial bloom.
Article in The ISME journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 107 citations in OpenAlex.
- Rolling circle transcription-based fluorescent aptasensor for highly sensitive and onsite detection of microcystin-LR.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Article
- Microbial diversity, genomics, and phage-host interactions of cyanobacterial harmful algal blooms.mSystems · 2024Article
- Plasmid-Borne Biosynthetic Gene Clusters within a Permanently Stratified Marine Water Column.Microorganisms · 2024Article
- Article
- Effect of stand age on rhizosphere microbial community assembly of dominant shrubs during sandy desert vegetation restoration.Frontiers in plant science · 2024Article
- Characterization and seasonal variation in biofilms attached to leaves of submerged plant.World journal of microbiology & biotechnology · 2023Article
- Expression ofApplied and environmental microbiology · 2023Article
- Transcription of biochemical defenses by the harmful brown tide pelagophyte,Frontiers in microbiology · 2023Article
- Evaluation of environmental factors and microbial community structure in an important drinking-water reservoir across seasons.Frontiers in microbiology · 2023Article
- Uptake of Phytoplankton-Derived Carbon and Cobalamins by NovelApplied and environmental microbiology · 2022Article
- Factors Driving Microbial Community Dynamics and Potential Health Effects of Bacterial Pathogen on Landscape Lakes with Reclaimed Water Replenishment in Beijing, PR China.International journal of environmental research and public health · 2022Article
- Coral mucus rapidly induces chemokinesis and genome-wide transcriptional shifts toward early pathogenesis in a bacterial coral pathogen.The ISME journal · 2021Article
- Co-occurring microorganisms regulate the succession of cyanobacterial harmful algal blooms.Environmental pollution (Barking, Essex : 1987) · 2021Article
- Competitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena.Scientific reports · 2021Article
- Metabarcoding profiling of microbial diversity associated with trout fish farming.Scientific reports · 2021Article
- Current Knowledge on Microviridin from Cyanobacteria.Marine drugs · 2021Review
- The Complicated and Confusing Ecology ofmBio · 2020Article
- Tracing the active genetic diversity of Microcystis and Microcystis phage through a temporal survey of Taihu.PloS one · 2020Article
- Cooccurrence of Broad- and Narrow-Host-Range Viruses Infecting the Bloom-Forming Toxic Cyanobacterium Microcystis aeruginosa.Applied and environmental microbiology · 2019Article
- Cyanobacterial biodiversity of semiarid public drinking water supply reservoirs assessed via next-generation DNA sequencing technology.Journal of microbiology (Seoul, Korea) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cyanobacterial harmful algal blooms (cyanoHABs) appear to be increasing in frequency on a global scale. The Cyanobacteria in blooms can produce toxic secondary metabolites that make freshwater dangerous for drinking and recreation. To characterize microbial activities in a cyanoHAB, transcripts from a eutrophic freshwater reservoir in Singapore were sequenced for six samples collected over one day-night period. Transcripts from the Cyanobacterium Microcystis dominated all samples and were accompanied by at least 533 genera primarily from the Cyanobacteria, Proteobacteria, Bacteroidetes and Actinobacteria. Within the Microcystis population, abundant transcripts were from genes for buoyancy, photosynthesis and synthesis of the toxin microviridin, suggesting that these are necessary for competitive dominance in the Reservoir. During the day, Microcystis transcripts were enriched in photosynthesis and energy metabolism while at night enriched pathways included DNA replication and repair and toxin biosynthesis. Microcystis was the dominant source of transcripts from polyketide and non-ribosomal peptide synthase (PKS and NRPS, respectively) gene clusters. Unexpectedly, expression of all PKS/NRPS gene clusters, including for the toxins microcystin and aeruginosin, occurred throughout the day-night cycle. The most highly expressed PKS/NRPS gene cluster from Microcystis is not associated with any known product. The four most abundant phyla in the reservoir were enriched in different functions, including photosynthesis (Cyanobacteria), breakdown of complex organic molecules (Proteobacteria), glycan metabolism (Bacteroidetes) and breakdown of plant carbohydrates, such as cellobiose (Actinobacteria). These results provide the first estimate of secondary metabolite gene expression, functional partitioning and functional interplay in a freshwater cyanoHAB.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.