ArticleBMJ (Clinical research ed.)2014
Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies.
Article in BMJ (Clinical research ed.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03348566 (Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Change), which is not on this map. Cited by 146 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Change
Who cites it
146 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Interactions between Polygenic Risk of Obesity and Dietary Factors on Anthropometric Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.The Journal of nutrition · 2024Pooled it
- FTO gene polymorphisms and obesity risk in Chinese population: a meta-analysis.World journal of pediatrics : WJP · 2019Pooled it
- Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis.BMJ (Clinical research ed.) · 2019Pooled it
- Assessment of the impact of a personalised nutrition intervention in impaired glucose regulation over 26 weeks: a randomised controlled trial.Scientific reports · 2024Trial
- Identification of genetic loci affecting body mass index through interaction with multiple environmental factors using structured linear mixed model.Scientific reports · 2021Trial
- Distinct genetic subtypes of adiposity and glycemic changes in response to weight-loss diet intervention: the POUNDS Lost trial.European journal of nutrition · 2021Trial
- Polygenic risk score for obesity and the quality, quantity, and timing of workplace food purchases: A secondary analysis from the ChooseWell 365 randomized trial.PLoS medicine · 2020Trial
- Habitual consumption of long-chain n-3 PUFAs and fish attenuates genetically associated long-term weight gain.The American journal of clinical nutrition · 2019Trial
- Genetic variation of habitual coffee consumption and glycemic changes in response to weight-loss diet intervention: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.The American journal of clinical nutrition · 2017Trial
- Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study.Nutrients · 2017Trial
- Genome-wide association study of the plasma triglyceride response to an n-3 polyunsaturated fatty acid supplementation.Journal of lipid research · 2014Trial
- A machine learning-derived polygenic risk score reveals that healthy lifestyle counteracts obesity-related mortality.NPJ digital medicine · 2026Article
- China precision nutrition biobank: protocol of a prospective cohort study on diet, human phenotype/genotype, and early-onset chronic diseases.Nutrition journal · 2025Article
- Interactive effects of sleep duration and dietary patterns on obesity moderated by age.Scientific reports · 2025Article
- Nutrition Practices for Healthy Living Across the Lifespan in Black/African American Men.Nutrients · 2025Article
- Polygenic prediction of body mass index and obesity through the life course and across ancestries.Nature medicine · 2025Article
- Sweet Taste Receptors' Genetic Variability in Advanced Potential Targets of Obesity.Nutrients · 2025Article
- Methylation Risk Score Modelling in Endometriosis: Evidence for Non-Genetic DNA Methylation Effects in a Case-Control Study.International journal of molecular sciences · 2025Article
- Precision medicine for obesity: current evidence and insights for personalization of obesity pharmacotherapy.International journal of obesity (2005) · 2025Review
- Role of Planetary Health Diet in the association between genetic susceptibility to obesity and anthropometric measures in adults.International journal of obesity (2005) · 2025Article
86 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors.
Funding
Abstract
objectiveTo examine the interactions between genetic predisposition and consumption of fried food in relation to body mass index (BMI) and obesity.
designProspective cohort study.
settingHealth professionals in the United States.
participants9623 women from the Nurses' Health Study, 6379 men from the Health Professionals Follow-up Study, and a replication cohort of 21,421 women from the Women's Genome Health Study.
main outcome measureRepeated measurement of BMI over follow-up.
resultsThere was an interaction between fried food consumption and a genetic risk score based on 32 BMI-associated variants on BMI in both the Nurses' Health Study and Health Professionals Follow-up Study (P ≤ 0.001 for interaction). Among participants in the highest third of the genetic risk score, the differences in BMI between individuals who consumed fried foods four or more times a week and those who consumed fried foods less than once a week amounted to 1.0 (SE 0.2) in women and 0.7 (SE 0.2) in men, whereas the corresponding differences were 0.5 (SE 0.2) and 0.4 (SE 0.2) in the lowest third of the genetic risk score. The gene-diet interaction was replicated in the Women's Genome Health Study (P<0.001 for interaction). Viewed differently, the genetic association with adiposity was strengthened with higher consumption of fried foods. In the combined three cohorts, the differences in BMI per 10 risk alleles were 1.1 (SE 0.2), 1.6 (SE 0.3), and 2.2 (SE 0.6) for fried food consumption less than once, one to three times, and four or more times a week (P<0.001 for interaction); and the odds ratios (95% confidence intervals) for obesity per 10 risk alleles were 1.61 (1.40 to 1.87), 2.12 (1.73 to 2.59), and 2.72 (2.12 to 3.48) across the three categories of consumption (P=0.002 for interaction). In addition, the variants in or near genes highly expressed or known to act in the central nervous system showed significant interactions with fried food consumption, with the FTO (fat mass and obesity associated) variant showing the strongest result (P<0.001 for interaction).
conclusionOur findings suggest that consumption of fried food could interact with genetic background in relation to obesity, highlighting the particular importance of reducing fried food consumption in individuals genetically predisposed to obesity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.