ReviewJournal of dental research2014
The Role of Oral Pathobionts in Dysbiosis during Periodontitis Development.
Review in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Microsurgery in periodontics and oral implantology: a systematic review of current clinical applications and outcomes.Evidence-based dentistry · 2024Pooled it
- Bacteria of healthy periodontal tissues as candidates of probiotics: a systematic review.European journal of medical research · 2024Pooled it
- Personalized antibiotic selection in periodontal treatment improves clinical and microbiological outputs.Frontiers in cellular and infection microbiology · 2023Trial
- Clinical study showing a lower abundance of Neisseria in the oral microbiome aligns with low birth weight pregnancy outcomes.Clinical oral investigations · 2022Trial
- Persistence of salivary antibody responses after COVID-19 vaccination is associated with oral microbiome variation in both healthy and people living with HIV.Frontiers in immunology · 2022Trial
- Differential profiles of soluble and cellular toll like receptor (TLR)-2 and 4 in chronic periodontitis.PloS one · 2018Trial
- Microbiota-based Signature of Gingivitis Treatments: A Randomized Study.Scientific reports · 2016Trial
- Comparative analysis of TNF-α, TLR-2, and TLR-4 in GCF before and after periodontal therapy.Brazilian oral research · 2026Article
- Recent perspectives on precision-targeting therapy against oral biofilm.Journal of oral microbiology · 2026Review
- Brain Structures, Circuits, and Networks Involved in Immune Regulation, Periodontal Health, and Disease.Life (Basel, Switzerland) · 2025Review
- The impact of vaping behavior on functional changes within the subgingival microbiome.Scientific reports · 2025Article
- Unveiling the Causal Roles of the Oral Microbiome-Host Metabolism-Inflammation Axis in Periodontitis: A Mendelian Randomisation Study.Oral health & preventive dentistry · 2025Article
- The impact of maternal oral microbiota on the risk of small vulnerable newborns: a nested case-control study.BMC oral health · 2025Article
- Laser and scanning electron microscopy evaluation of residual microislands of calculus.Journal of periodontology · 2025Article
- Oral microbiome and nitric oxide biomarkers in older people with mild cognitive impairment andPNAS nexus · 2025Article
- Cellulose Acetate Butyrate-Based In Situ Gel Comprising Doxycycline Hyclate and Metronidazole.Polymers · 2024Article
- Computational Studies on Recent Congeners of Fluoroquinolones and Nitroimidazoles for Their Use in Periodontal Therapy.Journal of pharmacy & bioallied sciences · 2024Article
- Associations between immune-inflammatory markers, age, and periodontal status: a cross-sectional study.Odontology · 2024Article
- Microbiota-immune-brain interactions: A new vision in the understanding of periodontal health and disease.Periodontology 2000 · 2024Review
- Oral Microbiome: A Review of Its Impact on Oral and Systemic Health.Microorganisms · 2024Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
An emerging concept is the tight relationship between dysbiosis (microbiota imbalance) and disease. The increase in knowledge about alterations in microbial communities that reside within the host has made a strong impact not only on dental science, but also on immunology and microbiology as well as on our understanding of several diseases. Periodontitis is a well-characterized human disease associated with dysbiosis, characterized by the accumulation of multiple bacteria that play individual and critical roles in bone loss around the teeth. Dysbiosis is largely dependent on cooperative and competitive interactions among oral microbes during the formation of the pathogenic biofilm community at gingival sites. Oral pathobionts play different and synergistic roles in periodontitis development, depending on their host-damaging and immunostimulatory activities. Host immune responses to oral pathobionts act as a double-edged sword not only by protecting the host against pathobionts, but also by promoting alveolar bone loss. Recent studies have begun to elucidate the roles of individual oral bacteria, including a new type of pathobionts that possess strong immunostimulatory activity, which is critical for alveolar bone loss. Better understanding of the roles of oral pathobionts is expected to lead to a better understanding of periodontitis disease and to the development of novel preventive and therapeutic approaches for the disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.