Evidence map›Paper›PMID 24646088›Full record

ArticleACS nano2014

Synthesis of fluorosurfactants for emulsion-based biological applications.

Ya-Ling Chiu, Hon Fai Chan, Kyle K L Phua, Ying Zhang, Sissel Juul, Birgitta R Knudsen, Yi-Ping Ho, Kam W Leong

Abstract read
In one paragraph

Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
  3. A Robust Synthesis of Fluorosurfactants with Tunable Functionalities via a Two-Step Reaction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Article
  5. Article
  6. Non-Ionic Fluorosurfactants for Droplet-Based in vivo Applications.Angewandte Chemie (International ed. in English) · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. On-demand light-driven release of droplets stabilizedMicrosystems & nanoengineering · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Acoustofluidic Synthesis of Particulate Nanomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ya-Ling ChiuDepartment of Biomedical Engineering, Duke University , North Carolina 27708, United States.
Hon Fai Chan
Kyle K L Phua
Ying Zhang
Sissel Juul
Birgitta R Knudsen
Yi-Ping Ho
Kam W Leong

Funding

Oral Therapy for Hemophilia AR01HL109442 · NHLBI · UNIVERSITY OF FLORIDA · PI DANIELL, HENRY, HERZOG, ROLAND W. · 2011 to 2015
$3.5M
Overcoming Immunosenescence by Nanoparticle-Mediated ActivationR01AI096305 · NIAID · DUKE UNIVERSITY · PI ABRAHAM, SOMAN N, LEONG, KAM W · 2012 to 2016
$1.8M
Derivation of Functional Neurons from Human Adult Cells by Nonviral Gene DeliveryR21EB015300 · NIBIB · DUKE UNIVERSITY · PI LEONG, KAM W · 2012 to 2013
$421k
NHLBI NIH HHS R01 HL109442NIAID NIH HHS AI096305NIAID NIH HHS R01 AI096305NIBIB NIH HHS EB015300NIBIB NIH HHS R21 EB015300
6 · The paper itself

Abstract

Microemulsion represents an attractive platform for fundamental and applied biomedical research because the emulsified droplets can serve as millions of compartmentalized micrometer-sized reactors amenable to high-throughput screening or online monitoring. However, establishing stable emulsions with surfactants that are compatible with biological applications remains a significant challenge. Motivated by the lack of commercially available surfactants suitable for microemulsion-based biological assays, this study describes the facile synthesis of a biocompatible fluorosurfactant with nonionic tris(hydroxymethyl)methyl (Tris) polar head groups. We have further demonstrated compatibility of the developed surfactant with diverse emulsion-based applications, including DNA polymeric nanoparticle synthesis, enzymatic activity assay, and bacterial or mammalian cell culture, in the setup of both double- and multiphases of emulsions.

Indexed as

Biocompatible MaterialsChemistry Techniques, SyntheticDNADNA Topoisomerases, Type IEmulsionsEnzyme AssaysEthersFluorocarbonsHalogenationHumansMesenchymal Stem CellsSpectroscopy, Fourier Transform InfraredSurface-Active AgentsBiocompatible MaterialsDNADNA Topoisomerases, Type IEmulsionsEthersFluorocarbonsperfluoropolyetherSurface-Active Agents

Identifiers

PMID24646088
PMCPMC4004322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.