ArticleBMC infectious diseases2014
Tuberculosis among people living with HIV/AIDS in the German ClinSurv HIV Cohort: long-term incidence and risk factors.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- HIV and tuberculosis co-infection in non-European migrants in Europe: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Tuberculosis in adult migrants in Europe: a TBnet consensus statement.The European respiratory journal · 2025Pooled it
- HIV and tuberculosis co-infection among migrants in Europe: A systematic review on the prevalence, incidence and mortality.PloS one · 2017Pooled it
- Tuberculosis after allogeneic hematopoietic stem cell transplantation: a decade nationwide case-control retrospective study in low-incidence country.Bone marrow transplantation · 2026Article
- Diagnostic Modality Influences Tuberculosis Detection in People Living with HIV: Eight Years of Data from a Thai Referral Center.Diagnostics (Basel, Switzerland) · 2025Article
- Tuberculosis prevalence and associated factors among persons infected with human immunodeficiency virus in three West African countries -(Benin, Guinea, Senegal).Multidisciplinary respiratory medicine · 2025Article
- Article
- Incidence and risk factors for HIV-tuberculosis coinfection in the Cologne-Bonn region: a retrospective cohort study.Infection · 2024Article
- Determinants of tuberculosis among adult people living with HIV on antiretroviral therapy at public hospitals in Hawassa City, South Ethiopia.Frontiers in epidemiology · 2024Article
- Predicting the risk of active pulmonary tuberculosis in people living with HIV: development and validation of a nomogram.BMC infectious diseases · 2022Article
- Tuberculosis screening coverage and isoniazid preventive therapy among people living with HIV at Gambella Hospital, southwest Ethiopia: a retrospective study design.The Journal of international medical research · 2021Article
- Time delay and associated mortality from negative smear to positive Xpert MTB/RIF test among TB/HIV patients: a retrospective study.BMC infectious diseases · 2019Article
- Injecting drug use predicts active tuberculosis in a national cohort of people living with HIV.AIDS (London, England) · 2017Article
- Immunological recovery in tuberculosis/HIV co-infected patients on antiretroviral therapy: implication for tuberculosis preventive therapy.BMC infectious diseases · 2017Article
- Survival of people living with HIV who defaulted from tuberculosis treatment in a cohort, Recife, Brazil.BMC infectious diseases · 2017Article
- Tuberculosis and HIV coinfection in Europe: looking at one reality from two angles.AIDS (London, England) · 2016Article
- Clinical Application of Interferon-γ Release Assays for the Prevention of Tuberculosis in Countries with Low Incidence.Pathogens & immunity · 2016Article
- Attitudes about tuberculosis prevention in the elimination phase: a survey among physicians in Germany.PloS one · 2014Article
- Impact of co-infections and BCG immunisation on immune responses among household contacts of tuberculosis patients in a Ugandan cohort.PloS one · 2014Article
- Intensified tuberculosis case finding, implementation of isoniazid preventive therapy and associated factors among people living with human immunodeficiency virus at public health facilities of Harari Region, Eastern Ethiopia: A cross-sectional study.International journal of health sciencesArticle
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Abstract
backgroundTuberculosis (TB) still presents a leading cause of morbidity and mortality among people living with HIV/AIDS (PLWHA), including those on antiretroviral therapy. In this study, we aimed to determine the long-term incidence density rate (IDR) of TB and risk factors among PLWHA in relation to combination antiretroviral therapy (cART)-status.
methodsData of PLWHA enrolled from 2001 through 2011 in the German ClinSurv HIV Cohort were investigated using survival analysis and Cox regression.
resultsTB was diagnosed in 233/11,693 PLWHA either at enrollment (N = 62) or during follow-up (N = 171). The TB IDR during follow-up was 0.37 cases per 100 person-years (PY) overall [95% CI, 0.32-0.43], and was higher among patients who never started cART and among patients originating from Sub-Saharan Africa (1.23 and 1.20 per 100PY, respectively). In two multivariable analyses, both patients (I) who never started cART and (II) those on cART shared the same risk factors for TB, namely: originating from Sub-Saharan Africa compared to Germany (I, hazard ratio (HR); [95% CI]) 4.05; [1.87-8.78] and II, HR 5.15 [2.76-9.60], CD4+ cell count <200 cells/μl (I, HR 8.22 [4.36-15.51] and II, HR 1.90 [1.14-3.15]) and viral load >5 log10 copies/ml (I, HR 2.51 [1.33-4.75] and II, HR 1.77 [1.11-2.82]). Gender, age or HIV-transmission risk group were not independently associated with TB.
conclusionIn the German ClinSurv HIV cohort, patients originating from Sub-Saharan Africa, with low CD4+ cell count or high viral load at enrollment were at increased risk of TB even after cART initiation. As patients might be latently infected with Mycobacterium tuberculosis complex, early screening for latent TB infection and implementing isoniazid preventive therapy in line with available recommendations is crucial.
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