Evidence map›Paper›PMID 24646020›Full record

ArticleNanomedicine (London, England)2014

Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues.

Dhirender Singh, JoEllyn M McMillan, Xin-Ming Liu, Hemant M Vishwasrao, Alexander V Kabanov, Marina Sokolsky-Papkov, Howard E Gendelman

Abstract read
In one paragraph

Article in Nanomedicine (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Immune cell engineering: opportunities in lung cancer therapeutics.Drug delivery and translational research · 2020
    Review
  8. Article
  9. Article
  10. Neurotheranostics as personalized medicines.Advanced drug delivery reviews · 2019
    Review
  11. Article
  12. Article
  13. Article
  14. Block copolymer conjugated Au-coated FeJournal of nanobiotechnology · 2017
    Article
  15. Article
  16. Mesoporous silica nanoparticles in target drug delivery system: A review.International journal of pharmaceutical investigation
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dhirender SinghDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
JoEllyn M McMillan
Xin-Ming Liu
Hemant M Vishwasrao
Alexander V Kabanov
Marina Sokolsky-Papkov
Howard E Gendelman

Funding

Targeted Neuro Protection of HIV-1 Associated Neurologic DiseaseP01MH064570 · NIMH · UNIVERSITY OF ROCHESTER · PI GELBARD, HARRIS A · 2001 to 2014
$19.4M
Pharmacokinetics and Drug-Drug InteractionsP01DA028555 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BOSKA, MICHAEL DOUGLAS · 2010 to 2019
$16.8M
Neuroprotective Immunity and HIV DementiaR01NS034239 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Howard E Gendelman, R Lee Mosley · 1995 to 2026
$12.3M
Proteomics CoreP01NS043985 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BOSKA, MICHAEL DOUGLAS · 2003 to 2012
$11.8M
Nanomedicine and NeuroAIDSR01NS036126 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 1997 to 2017
$5.7M
SMART HANDR01AG043540 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E, POLUEKTOVA, LARISA Y · 2013 to 2017
$3.1M
NEBRASKA CENTER FOR VIROLOGY: AIDSP30RR031151 · NCRR · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2010 to 2011
$2.9M
NCRR NIH HHS P30 RR031151NCRR NIH HHS P30RR031151NIA NIH HHS R01 AG043540NIDA NIH HHS 1P01DA028555NIDA NIH HHS P01 DA028555NIMH NIH HHS P01 MH064570NIMH NIH HHS P01MH64570NINDS NIH HHS 2R01NS034239NINDS NIH HHS 2R01NS36126NINDS NIH HHS P01 NS043985NINDS NIH HHS P01NS43985NINDS NIH HHS R01 NS034239NINDS NIH HHS R01 NS036126
6 · The paper itself

Abstract

Magnetic nanoparticles (MNPs) accumulate at disease sites with the aid of magnetic fields; biodegradable MNPs can be designed to facilitate drug delivery, influence disease diagnostics, facilitate tissue regeneration and permit protein purification. Because of their limited toxicity, MNPs are widely used in theranostics, simultaneously facilitating diagnostics and therapeutics. To realize therapeutic end points, iron oxide nanoparticle cores (5-30 nm) are encapsulated in a biocompatible polymer shell with drug cargos. Although limited, the toxic potential of MNPs parallels magnetite composition, along with shape, size and surface chemistry. Clearance is hastened by the reticuloendothelial system. To surmount translational barriers, the crystal structure, particle surface and magnetic properties of MNPs need to be optimized. With this in mind, we provide a comprehensive evaluation of advancements in MNP synthesis, functionalization and design, with an eye towards bench-to-bedside translation.

Indexed as

Biocompatible MaterialsChemical PrecipitationDrug Delivery SystemsEmulsionsMagnetite NanoparticlesNanotechnologyPharmaceutical PreparationsPolymersSurface PropertiesTemperatureThermodynamicsBiocompatible MaterialsEmulsionsMagnetite NanoparticlesPharmaceutical PreparationsPolymers

Identifiers

PMID24646020
PMCPMC4338921

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.