Evidence map›Paper›PMID 24645944›Full record

Trial reportThe New England journal of medicine2014

Late outcomes of a randomized trial of high-frequency oscillation in neonates.

Sanja Zivanovic, Janet Peacock, Mireia Alcazar-Paris, Jessica W Lo, Alan Lunt, Neil Marlow, Sandy Calvert, Anne Greenough

Open access · bronzeAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The New England journal of medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 137 citations in OpenAlex.

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  20. Senescence of lung mesenchymal stem cells of preterm infants by cyclic stretch and hyperoxia via p21.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Sanja Zivanovic *Author affiliations: Division of Asthma, Allergy and Lung Biology, Medical Research Council Centre for Allergic Mechanisms in Asthma (S.Z., M.A.-P., A.L., A.G.), and the Division of Health and Social Care Research (J.P., J.W.L.), King's College London, the National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust and King's College London (S.Z., J.P., J.W.L., A.L., A.G.), the Institute for Women's Health, University College London (N.M.), and the Department of Child Health, St. George's, University of London (S.C.) - all in London.
Janet Peacock *Author affiliations: Division of Asthma, Allergy and Lung Biology, Medical Research Council Centre for Allergic Mechanisms in Asthma (S.Z., M.A.-P., A.L., A.G.), and the Division of Health and Social Care Research (J.P., J.W.L.), King's College London, the National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust and King's College London (S.Z., J.P., J.W.L., A.L., A.G.), the Institute for Women's Health, University College London (N.M.), and the Department of Child Health, St. George's, University of London (S.C.) - all in London.
Mireia Alcazar-ParisAuthor affiliations: Division of Asthma, Allergy and Lung Biology, Medical Research Council Centre for Allergic Mechanisms in Asthma (S.Z., M.A.-P., A.L., A.G.), and the Division of Health and Social Care Research (J.P., J.W.L.), King's College London, the National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust and King's College London (S.Z., J.P., J.W.L., A.L., A.G.), the Institute for Women's Health, University College London (N.M.), and the Department of Child Health, St. George's, University of London (S.C.) - all in London.
Jessica W LoAuthor affiliations: Division of Asthma, Allergy and Lung Biology, Medical Research Council Centre for Allergic Mechanisms in Asthma (S.Z., M.A.-P., A.L., A.G.), and the Division of Health and Social Care Research (J.P., J.W.L.), King's College London, the National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust and King's College London (S.Z., J.P., J.W.L., A.L., A.G.), the Institute for Women's Health, University College London (N.M.), and the Department of Child Health, St. George's, University of London (S.C.) - all in London.
Alan LuntAuthor affiliations: Division of Asthma, Allergy and Lung Biology, Medical Research Council Centre for Allergic Mechanisms in Asthma (S.Z., M.A.-P., A.L., A.G.), and the Division of Health and Social Care Research (J.P., J.W.L.), King's College London, the National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust and King's College London (S.Z., J.P., J.W.L., A.L., A.G.), the Institute for Women's Health, University College London (N.M.), and the Department of Child Health, St. George's, University of London (S.C.) - all in London.
Neil MarlowAuthor affiliations: Division of Asthma, Allergy and Lung Biology, Medical Research Council Centre for Allergic Mechanisms in Asthma (S.Z., M.A.-P., A.L., A.G.), and the Division of Health and Social Care Research (J.P., J.W.L.), King's College London, the National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust and King's College London (S.Z., J.P., J.W.L., A.L., A.G.), the Institute for Women's Health, University College London (N.M.), and the Department of Child Health, St. George's, University of London (S.C.) - all in London.
Sandy CalvertAuthor affiliations: Division of Asthma, Allergy and Lung Biology, Medical Research Council Centre for Allergic Mechanisms in Asthma (S.Z., M.A.-P., A.L., A.G.), and the Division of Health and Social Care Research (J.P., J.W.L.), King's College London, the National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust and King's College London (S.Z., J.P., J.W.L., A.L., A.G.), the Institute for Women's Health, University College London (N.M.), and the Department of Child Health, St. George's, University of London (S.C.) - all in London.
Anne GreenoughAuthor affiliations: Division of Asthma, Allergy and Lung Biology, Medical Research Council Centre for Allergic Mechanisms in Asthma (S.Z., M.A.-P., A.L., A.G.), and the Division of Health and Social Care Research (J.P., J.W.L.), King's College London, the National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust and King's College London (S.Z., J.P., J.W.L., A.L., A.G.), the Institute for Women's Health, University College London (N.M.), and the Department of Child Health, St. George's, University of London (S.C.) - all in London.
Medical Research Council · GBNational Health Service · GBKing's College London · GBNIHR Biomedical Research Centre at The Royal Marsden and the ICRSt George's, University of London · GBUniversity College London · GB

Funding

Department of Health 08/116/10Department of Health HTA/08/116/10
6 · The paper itself

Abstract

backgroundResults from an observational study involving neonates suggested that high-frequency oscillatory ventilation (HFOV), as compared with conventional ventilation, was associated with superior small-airway function at follow-up. Data from randomized trials are needed to confirm this finding.

methodsWe studied 319 adolescents who had been born before 29 weeks of gestation and had been enrolled in a multicenter, randomized trial that compared HFOV with conventional ventilation immediately after birth. The trial involved 797 neonates, of whom 592 survived to hospital discharge. We compared follow-up data from adolescents who had been randomly assigned to HFOV with follow-up data from those who had been randomly assigned to conventional ventilation, with respect to lung function and respiratory health, health-related quality of life, and functional status, as assessed with the use of questionnaires completed when the participants were 11 to 14 years of age. The primary outcome was forced expiratory flow at 75% of the expired vital capacity (FEF75).

resultsThe HFOV group had superior results on a test of small-airway function (z score for FEF75, -0.97 with HFOV vs. -1.19 with conventional therapy; adjusted difference, 0.23 [95% confidence interval, 0.02 to 0.45]). There were significant differences in favor of HFOV in several other measures of respiratory function, including forced expiratory volume in 1 second, forced vital capacity, peak expiratory flow, diffusing capacity, and impulse-oscillometric findings. As compared with the conventional-therapy group, the HFOV group had significantly higher ratings from teachers in three of eight school subjects assessed, but there were no other significant differences in functional outcomes.

conclusionsIn a randomized trial involving children who had been born extremely prematurely, those who had undergone HFOV, as compared with those who had received conventional ventilation, had superior lung function at 11 to 14 years of age, with no evidence of poorer functional outcomes. (Funded by the National Institute for Health Research Health Technology Assessment Programme and others.).

Indexed as

Forced Expiratory Flow RatesHigh-Frequency VentilationInfant, Extremely PrematureRespirationAdolescentChildFemaleFollow-Up StudiesHumansInfant, NewbornMaleQuality of LifeRespiration, Artificial

Identifiers

PMID24645944
PMCPMC4090580
OpenAlexW2157302622

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.