ArticleBMC gastroenterology2014
A retrospective study showing maintenance treatment options for paediatric CD in the first year following diagnosis after induction of remission with EEN: supplemental enteral nutrition is better than nothing!
Article in BMC gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Partial Enteral Nutrition in the Management of Crohn's Disease: A Systematic Review and Meta-Analysis.Journal of Crohn's & colitis · 2025Pooled it
- Nutrition in Pediatric Inflammatory Bowel Disease: From Etiology to Treatment. A Systematic Review.Nutrients · 2016Pooled it
- Effect of ModulenWorld journal of gastroenterology · 2025Trial
- Enteral nutrition versus immunomodulators for induction and maintenance of remission in pediatric Crohn's disease: a systematic review and network meta-analysis.Frontiers in pediatrics · 2026Review
- Outcome of pediatric inflammatory bowel disease in Asian children: a multinational 1-year follow-up study.Clinical and experimental pediatrics · 2025Article
- Revolution in diet therapy for inflammatory bowel disease.JGH open : an open access journal of gastroenterology and hepatology · 2024Review
- Role of diet in prevention versus treatment of Crohn's disease and ulcerative colitis.Frontline gastroenterology · 2024Review
- Dietary interventions in Crohn's disease: A simple solution to refractory disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Article
- Article
- Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn's Disease; A Feasibility Study.Nutrients · 2022Article
- Global attitudes on and the status of enteral nutrition therapy for pediatric inflammatory bowel disease.Frontiers in medicine · 2022Review
- Nutritional Therapies and Their Influence on the Intestinal Microbiome in Pediatric Inflammatory Bowel Disease.Nutrients · 2021Review
- Diet and nutrition in the management of inflammatory bowel disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Review
- Dietary Management in Pediatric Patients with Crohn's Disease.Nutrients · 2021Review
- How Can a Polymeric Formula Induce Remission in Crohn's Disease Patients?International journal of molecular sciences · 2021Review
- Diet and Nutrition in Pediatric Inflammatory Bowel Diseases.Nutrients · 2021Review
- Dietary Strategies for Maintenance of Clinical Remission in Inflammatory Bowel Diseases: Are We There Yet?Nutrients · 2020Review
- Predictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn´s Disease in Children: PRESENCE Study from SEGHNP.Nutrients · 2020Observational
- ORAL AND ENTERAL NUTRITION THERAPY IN INFLAMMATORY BOWEL DISEASES AMONG THE PEDIATRIC POPULATION: A LITERATURE REVIEW.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020Review
- The reduction of faecal calprotectin during exclusive enteral nutrition is lost rapidly after food re-introduction.Alimentary pharmacology & therapeutics · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA limited body of research suggests that ongoing maintenance enteral nutrition (MEN) can be beneficial in maintaining disease remission in Crohn's Disease (CD). We aimed to assess how achievable MEN is and whether it helps to prolong remission.
methodsPatients newly diagnosed with CD in 2010 and 2011 who commenced exclusive enteral nutrition (EEN) for 8 weeks were followed up for a year post diagnosis. All patients who took EEN were encouraged to continue MEN post EEN. Data on azathioprine use was also collected. Categorical variables were compared using chi-square/Fischer's exact test. Medians were expressed along with complete data ranges.
results59 patients (34 male, median age 11.07 years, range 2.5-16.33 years) were identified. 11/59 (18%) had a poor response to EEN and were switched to steroids. 48/59 patients completed 8 weeks EEN and achieved clinical remission/response. 46/48 patients received Modulen IBD®, 29/48 (60%) consumed EEN orally and 19/48 (40%) via NGT. 15/48 (31%) patients were able to continue MEN post EEN completion. MEN was consumed for a mean of 10.8 months (range 4-14 months). 14/15 patients drank MEN and 1/15 had MEN via NGT. Remission rates at 1 year in patients continuing MEN were 60% (9/15) compared to 15% (2/13) in patients taking no treatment (p = 0.001) and 65% (13/20) in patients taking azathioprine (p = 0.14).
conclusionA sub group of patients can continue MEN as a maintenance treatment and this seems a useful strategy, especially in those who are not commencing azathioprine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.