ArticleBMC neuroscience2014
Association of anxiety with intracortical inhibition and descending pain modulation in chronic myofascial pain syndrome.
Article in BMC neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 59 citations in OpenAlex.
- Home-Based Transcranial Direct Current Stimulation vs Placebo for Fibromyalgia: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Mental imagery-induced attention modulates pain perception and cortical excitability.BMC neuroscience · 2015Trial
- Sensing vs. seeing: body experience rather than mere body observation is linked to efficiency of descending pain modulation.Scientific reports · 2026Article
- A cross-sectional study of the association between the lymphocyte to high-density lipoprotein ratio and pain in parkinson's disease.Experimental brain research · 2026Article
- Conditioned pain modulation, cortical imbalance, and arthrogenic muscle inhibition: an integrative model with implications for exercise in chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Anxiety as a Psychological Modulator of Endogenous Pain Inhibition in Chronic Neck Pain: Implications for Precision Rehabilitation.Journal of pain research · 2026Article
- A review of descending pain modulation in humans.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Amelioration of emotional processing deficits in individuals with high trait anxiety following high-intensity interval training.BMC psychology · 2025Article
- Effects of Autogenic Training on Pain Modulation in Burning Mouth Syndrome: A Preliminary Study.Cureus · 2025Article
- Pain in Parkinson's disease is impacted by motor complications, anxiety and sleep disturbances.European journal of pain (London, England) · 2025Observational
- An Innovative EEG-Based Pain Identification and Quantification: A Pilot Study.Sensors (Basel, Switzerland) · 2024Article
- Testing Biological and Psychological Pathways of Emotion Regulation as a Primary Mechanism of Action in Yoga Interventions for Chronic Low Back Pain: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2024Article
- Effect of Mirror Therapy on Post-Needling Pain Following Deep Dry Needling of Myofascial Trigger Point in Lateral Elbow Pain: Prospective Controlled Pilot Trial.Journal of clinical medicine · 2024Article
- Deficits in Emotional Perception-Related Motor Cortical Excitability in Individuals With Trait Anxiety: A Transcranial Magnetic Stimulation Study.Depression and anxiety · 2024Article
- Involvement of Oxidative Stress and Nutrition in the Anatomy of Orofacial Pain.International journal of molecular sciences · 2023Review
- Relationship between self-reported pain, pain threshold, pain catastrophization and quality of life in patients with TMD.Journal of clinical and experimental dentistry · 2023Article
- Article
- Towards the Objective Identification of the Presence of Pain Based on Electroencephalography Signals' Analysis: A Proof-of-Concept.Sensors (Basel, Switzerland) · 2022Article
- Conditioning to Enhance the Effects of Repetitive Transcranial Magnetic Stimulation on Experimental Pain in Healthy Volunteers.Frontiers in psychiatry · 2022Article
- Temporal Summation in Fibromyalgia Patients: Comparing Phasic and Tonic Paradigms.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to answer three questions related to chronic myofascial pain syndrome (MPS): 1) Is the motor cortex excitability, as assessed by transcranial magnetic stimulation parameters (TMS), related to state-trait anxiety? 2) Does anxiety modulate corticospinal excitability changes after evoked pain by Quantitative Sensory Testing (QST)? 3) Does the state-trait anxiety predict the response to pain evoked by QST if simultaneously receiving a heterotopic stimulus [Conditional Pain Modulation (CPM)]? We included females with chronic MPS (n = 47) and healthy controls (n = 11), aged 19 to 65 years. Motor cortex excitability was assessed by TMS, and anxiety was assessed based on the State-Trait Anxiety Inventory. The disability related to pain (DRP) was assessed by the Profile of Chronic Pain scale for the Brazilian population (B:PCP:S), and the psychophysical pain measurements were measured by the QST and CPM.
resultsIn patients, trait-anxiety was positively correlated to intracortical facilitation (ICF) at baseline and after QST evoked pain (β = 0.05 and β = 0.04, respectively) and negatively correlated to the cortical silent period (CSP) (β = -1.17 and β = -1.23, respectively) (P <0.05 for all comparisons). After QST evoked pain, the DRP was positively correlated to ICF (β = 0.02) (P < 0.05). Pain scores during CPM were positively correlated with trait-anxiety when it was concurrently with high DRP (β = 0.39; P = 0.02). Controls' cortical excitability remained unchanged after QST.
conclusionsThese findings suggest that, in chronic MPS, the imbalance between excitatory and inhibitory descending systems of the corticospinal tract is associated with higher trait-anxiety concurrent with higher DRP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.