ArticleIranian journal of psychiatry and behavioral sciences2011
The Efficacy of Intermittent Walking in Water on the Rate of MHPG Sulfate and the Severity of Depression.
Article in Iranian journal of psychiatry and behavioral sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 15 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 15 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The Effects of Physical Activity Intervention on Depression Symptoms in Children and Adolescents: A Meta-analysis of Randomized Controlled Trials.International journal of behavioral medicine · 2026Pooled it
- Aerobic exercise for depression symptoms in adolescents: a systematic review and dose-response meta-analysis.BMC public health · 2026Pooled it
- Impact of Structured Physical Exercise on Adolescent Depression: A Comprehensive Meta-Analysis of RCTs.CNS & neurological disorders drug targets · 2026Pooled it
- Disentangling the biological mechanisms underlying the effects of physical exercise in major depressive disorder: a comprehensive systematic review of randomized controlled trials.Psychological medicine · 2025Pooled it
- Comparative effects of exercise type and dose on depression in children and adolescents: a network meta-analysis.Frontiers in psychology · 2025Pooled it
- Aerobic exercise strategies for anxiety and depression among children and adolescents: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- The Effect of Walking on Depressive and Anxiety Symptoms: Systematic Review and Meta-Analysis.JMIR public health and surveillance · 2024Pooled it
- The influence of physical exercise on negative emotions in adolescents: a meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Comparing the efficacy of different types of exercise for the treatment and prevention of depression in youths: a systematic review and network meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Comparative Effectiveness of Multiple Exercise Interventions in the Treatment of Mental Health Disorders: A Systematic Review and Network Meta-Analysis.Sports medicine - open · 2022Pooled it
- The strategies of exercise intervention for adolescent depression: A meta-analysis of randomized controlled trials.Frontiers in psychology · 2022Pooled it
- Meta-analysis and systematic review of physical activity on neurodevelopment disorders, depression, and obesity among children and adolescents.Frontiers in psychology · 2022Pooled it
- Physical Activity for the Treatment of Adolescent Depression: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2020Pooled it
- Systematic Review of Meta-Analyses: Exercise Effects on Depression in Children and Adolescents.Frontiers in psychiatry · 2020Pooled it
- Exercise for depression.The Cochrane database of systematic reviews · 2013Pooled it
- Comparative effects of various exercise interventions on anxiety and depression symptoms in children and adolescents: a network meta-analysis of randomized controlled trials.European child & adolescent psychiatry · 2026Review
- Physical activity, exercise, and mental health of healthy adolescents: A review of the last 5 years.Sports medicine and health science · 2025Review
- [The German S3 guideline for depressive disorders in childhood and adolescence: new developments].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023Review
- Article
- Systematic review and meta-analysis of the effects of exercise on depression in adolescents.Child and adolescent psychiatry and mental health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMany studies evaluated the efficacy of exercise on some depression indices, but the effect of physical exercise in exhilarating milieu on urine 3-Methoxy-4-Hydroxyphenylglycol (MHPG) sulfate-the main metabolite of norepinephrine is not clear. The purpose of this research was to study the effect of a six-week intermittent walking in the water on 24-hour urine MHPG sulfate in depressed female teenagers.
methodsTwenty-four high school female students with depression were divided randomly into case and control group. Pool walking exercise program was implemented 3 sessions weekly for 6 weeks and with a rate of 60-70% of the maximum heart rate. The control group didn't enter any exercise protocol and did not receive any other anti-depressant therapy. HPLC-fluorometric detection assay was used to measure 24-hour urine MHPG sulfate values. The data was analyzed with t-test and Pierson's correlation tests.
resultsTwenty hour urine MHPG sulfate increased from 1.93 (±0.59) to 4.66 (±0.85) micromole in case group (P ≤ 0.001), and in control group from 1.67 (±0.58) to 1.80 (±0.58) micromole. Increase of 24-hour urine MHPG sulfate and increasing of maximum oxygen consumption showed significant positive correlation (r = 0.65), and a significant negative correlation (r = 0.65) was observed between urine MHPG sulfate and Hamilton Rating Scale for Depression (Ham-D) score.
conclusionAerobics training in exhilarating environments shows desirable influence over reduction of depression. This reduction of depression is correlated with MHPG sulfate elevation.
Indexed as
Identifiers
24644444PMC3939959W2157200429What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.