ArticleBritish journal of pharmacology1988
Effects and interactions of sensory neuropeptides on airway microvascular leakage in guinea-pigs.
Article in British journal of pharmacology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 131 citations in OpenAlex.
- Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2.British journal of pharmacology · 2016Article
- Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux.British journal of pharmacology · 2005Article
- Nociceptin inhibits airway microvascular leakage induced by HCl intra-oesophageal instillation.British journal of pharmacology · 2004Article
- Tachykinins via Tachykinin NK(2) receptor activation mediate ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs.British journal of pharmacology · 2002Article
- Neurogenic plasma leakage in mouse airways.British journal of pharmacology · 1999Article
- A new pharyngitis model using capsaicin in rats.General pharmacology · 1998Article
- Involvement of hydroxyl radicals in neurogenic airway plasma exudation and bronchoconstriction in guinea-pigs in vivo.British journal of pharmacology · 1996Article
- Activation of the micturition reflex by NK2 receptor stimulation in the anaesthetized guinea-pig.British journal of pharmacology · 1995Article
- Distribution of SP- and CGRP-like immunoreactive nerve fibers in the lower respiratory tract of neonatal foals: evidence for loss during development.Anatomy and embryology · 1994Article
- Inhibition of substance P-induced microvascular leakage by inhaled methoxamine in rat airways.British journal of pharmacology · 1994Article
- Differential effects of phosphoramidon and captopril on NK1 receptor-mediated plasma extravasation in the rat trachea.Agents and actions · 1994Article
- Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences.British journal of pharmacology · 1994Article
- Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.British journal of pharmacology · 1993Article
- Attenuation of tachykinin-induced airflow obstruction and microvascular leakage in immature airways.British journal of pharmacology · 1993Article
- Formoterol and salbutamol inhibit bradykinin- and histamine-induced airway microvascular leakage in guinea-pig.British journal of pharmacology · 1992Article
- Inhibition of neurogenic plasma exudation in guinea-pig airways by CP-96,345, a new non-peptide NK1 receptor antagonist.British journal of pharmacology · 1992Article
- Article
- Differential effects of phosphoramidon on neurokinin A- and substance P-induced airflow obstruction and airway microvascular leakage in guinea-pig.British journal of pharmacology · 1991Article
- Calcitonin gene related peptide.BMJ (Clinical research ed.) · 1991Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. We have studied the effect of the sensory neuropeptides substance P (SP), neurokinin A (NKA), neurokinin B (NKB) and calcitonin gene-related peptide (CGRP) on microvascular permeability in guinea-pig airways in vivo and investigated whether CGRP would potentiate the effect of SP. We used the extravasation of intravenously-injected Evans blue dye as an index of permeability. 2. The tachykinins SP, NKA and NKB (0.025-5.0 nmol kg-1, i.v.) significantly (P less than 0.05) increased extravasation of dye in a dose-related manner and with a similar pattern of distribution; they were most potent in the trachea and main bronchi, less potent in the larynx and intrapulmonary airways, and had little significant effect in the bladder. 3. SP was significantly more potent in causing extravasation of dye than NKA or NKB with ED50 values (nmol kg-1) in the range 0.04-0.1, depending on the airway level, compared with values in the range 0.3-0.7 for the neurokinins. 4. CGRP (0.0025-2.5 nmol kg-1, i.v.) had no significant effect on microvascular permeability and did not potentiate SP-induced extravasation of dye. 5. Each neuropeptide decreased mean arterial blood pressure, indicating vasodilatation, in a dose-related manner. Co-injection of CGRP and SP produced additive decreases in arterial pressure. 6. We conclude that, in guinea-pig airways, tachykinins increase microvascular permeability via tachykinin receptors of the NK-1 sub-type (indicated by an order of potency of SP greater than NKA = NKB) on endothelial cells. The response appears to be related to mechanisms in addition to vasodilatation. The relevance of the responses to the tachykinins in asthma is discussed.
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