ArticleScience signaling2014
Mechano-chemo transduction tunes the heartstrings.
Article in Science signaling, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures.The Journal of physiology · 2022Article
- Article
- Automatic detection of adult cardiomyocyte for high throughput measurements of calcium and contractility.PloS one · 2021Article
- Role of neuronal nitric oxide synthase on cardiovascular functions in physiological and pathophysiological states.Nitric oxide : biology and chemistry · 2020Review
- Cardiac microtubules in health and heart disease.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Mechanical Communication Acts as a Noise Filter.iScience · 2019Article
- Theory of frequency response of mechanically driven cardiomyocytes.Scientific reports · 2018Article
- The Influence of the Timing of Cyclic Load Application on Cardiac Cell Contraction.Frontiers in physiology · 2018Article
- Modeling Local X-ROS and Calcium Signaling in the Heart.Biophysical journal · 2015Article
- Mechanotransduction in cardiac hypertrophy and failure.Circulation research · 2015Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In the beating heart, mechanical stretch triggers the production of reactive oxygen or nitrogen species that target Ca(2+)-signaling proteins. Termed mechano-chemo transduction, this pathway "tunes" the calcium release machinery in the healthy heart; when dysregulated, it contributes to disease. In this issue of Science Signaling, Jian et al. used a "cell-in-gel" method to show that contractions in healthy heart cells elicit a steep, viscosity-dependent increase in mechano-chemo transduction in which nitric oxide synthase (NOS), NADPH oxidase 2 (Nox2), and Ca(2+)/calmodulin-dependent kinase II (CaMKII) contribute. These authors provide evidence for a role of neuronal NOS (nNOS) over endothelial NOS; they supported their findings with super-resolution microscopy, which localized nNOS nearest to the Ca(2+) release sites. In a disease model, signaling through nNOS and CaMKII rather than through Nox2 was enhanced, supporting the independent mechano-activation of these enzymes. The coupling of these quantitative approaches will provide a new understanding of mechano-chemo transduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.