Evidence map›Paper›PMID 24643739›Full record

ReviewPediatric nephrology (Berlin, Germany)2015

Diabetic kidney disease in children and adolescents.

Maryam Afkarian

Open access · bronzeAbstract readReview
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Diabetic Kidney Disease: It Don't Get No Respect.Clinical diabetes : a publication of the American Diabetes Association · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Maryam AfkarianUniversity of Washington, Medicine, 325 9th Avenue, Box 359606, Seattle, WA, 98104, USA, afkarian@uw.edu.
Seattle University · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Molecular signatures of diabetic kidney diseaseR01DK104706 · NIDDK · UNIVERSITY OF WASHINGTON · PI AFKARIAN, MARYAM · 2015 to 2017
$1.3M
Identifying urinary biomarkers for early type 2 diabetic nephropathyK23DK089017 · NIDDK · UNIVERSITY OF WASHINGTON · PI AFKARIAN, MARYAM · 2010 to 2014
$745k
NIDDK NIH HHS K23 DK089017NIDDK NIH HHS K23DK089017NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK104706
6 · The paper itself

Abstract

Diabetes, more frequently type 1, but increasingly also type 2, commonly occurs in childhood. While more advanced diabetic kidney disease (DKD), e.g., loss of glomerular filtration rate (GFR), does not occur until adulthood, kidney biopsies show DKD structural changes as early as 1.5-5 years after the onset of type 1 diabetes. Earliest clinical sign of DKD, increased urine albumin excretion, commonly appears during childhood and adolescence and presents an important opportunity to detect and intervene in early DKD, perhaps more successfully than later in the disease course. Longitudinal studies of type 1 diabetes have enriched our understanding of the DKD natural history and modifiable risk factors for DKD progression. These studies have also shown that the presence of DKD marks a subset of people with diabetes who are at the highest risk of early mortality, supporting an enhanced focus on DKD detection, prevention, and treatment. Early studies suggest that youth-onset type 2 diabetes is associated with a higher prevalence of comorbidities and risk factors and follows a more aggressive natural history. A deeper understanding of the natural history, risk factors, underlying mechanisms and therapeutic options for DKD in young-onset type 2 diabetes awaits further studies.

Indexed as

AdolescentChildDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NephropathiesHumans

Identifiers

PMID24643739
PMCPMC4169353
OpenAlexW2137756473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.