ArticleMicrobial ecology2014
Characterization of aid1, a novel gene involved in Fusobacterium nucleatum interspecies interactions.
Article in Microbial ecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Probiotics Exert Colonization Resistance AgainstMicroorganisms · 2026Article
- Cascade Therapy of Periodontitis via Sequential Release of Ribosome-Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF-Based System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Oral microbiome contribution in colorectal carcinogenesis: polymicrobial interactions and virulence determinants.Frontiers in cellular and infection microbiology · 2026Review
- Fusobacterium nucleatum interacts with cancer-associated fibroblasts to promote colorectal cancer.The EMBO journal · 2025Article
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- Interaction BetweenMicroorganisms · 2025Article
- Establishment and improvement of genetic manipulation tools forEngineering microbiology · 2025Review
- Bacterial profiling of colorectal cancer biopsies: a culture-based study in Indian patients.Frontiers in cellular and infection microbiology · 2025Article
- Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance.Cell communication and signaling : CCS · 2024Review
- Periodontal pathogens and cancer development.Periodontology 2000 · 2024Review
- Coaggregated E. faecalis with F. nucleatum regulated environmental stress responses and inflammatory effects.Applied microbiology and biotechnology · 2024Article
- Emerging strategies for combatingExploration (Beijing, China) · 2024Review
- Targeted elimination ofJournal of oral microbiology · 2024Article
- The Role ofMicroorganisms · 2023Review
- Akkermansia muciniphila inhibited the periodontitis caused by Fusobacterium nucleatum.NPJ biofilms and microbiomes · 2023Article
- Antagonistic interaction between two key endodontic pathogensJournal of oral microbiology · 2023Article
- Review
- The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions.Frontiers in microbiology · 2022Review
- More Than Just a Periodontal Pathogen -the Research Progress onFrontiers in cellular and infection microbiology · 2022Review
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Authors and funding
6 authors.
Funding
Abstract
The oral opportunistic pathogen Fusobacterium nucleatum is known to interact with a large number of different bacterial species residing in the oral cavity. It adheres to a variety of Gram-positive bacteria, including oral streptococci via the arginine-inhibitable adhesin RadD. In this study, we describe a novel protein encoded by the predicted open reading frame FN1253 that appears to play a role in interspecies interactions of F. nucleatum, particularly with oral streptococci and related Gram-positive species. We designated FN1253 as aid1 (Adherence Inducing Determinant 1). Expression analyses demonstrated that this gene was induced in F. nucleatum single species biofilms, while the presence of representative members of the oral microbiota known to adhere to F. nucleatum triggered its suppression. Inactivation as well as overexpression of aid1 affected the ability of F. nucleatum to coaggregate with oral streptococci and the closely related Enterococcus faecalis, but not other Gram-positive oral species tested. Furthermore, overexpression of aid1 led to a drastic change in the structure of dual species biofilms of F. nucleatum with oral streptococci. Aid1 function was abolished in the presence of arginine and found to be dependent on RadD. Interestingly, differential expression of aid1 did not affect messenger RNA and protein levels of RadD. These findings indicate that RadD-mediated adhesion to oral streptococci involves more complex cellular processes than the simple interaction of adhesins on the surface of partner strains. Aid1 could potentially play an important role in facilitating RadD-mediated interaction with oral streptococci by increasing binding specificity of F. nucleatum to other microbial species.
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