ArticleThe Journal of pharmacology and experimental therapeutics2014
Acute ethanol inhibits dopamine release in the nucleus accumbens via α6 nicotinic acetylcholine receptors.
Article in The Journal of pharmacology and experimental therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 44 citations in OpenAlex.
- Adolescent social isolation associated changes in ethanol-induced dopamine regulation in the ventral pallidum.Addiction neuroscience · 2025Article
- "Unraveling the role ofReceptors (Basel, Switzerland) · 2025Article
- The superoxide dismutase mimetic TEMPOL modulates nicotine-induced hyperlocomotor activity and nicotine-taking behavior in male rats.Scientific reports · 2025Article
- Monoamine Transporters in Drugs of Abuse: Insights from Fast Scan Cyclic Voltammetry.Advances in neurobiology · 2025Review
- Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025Review
- Cholinergic mu-opioid receptor deletion alters reward preference and aversion-resistance.Neuropharmacology · 2024Article
- Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters.ACS chemical neuroscience · 2024Article
- Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function.Cell & bioscience · 2024Article
- GDNF gene therapy for alcohol use disorder in male non-human primates.Nature medicine · 2023Article
- Role of α6-Nicotinic Receptors in Alcohol-Induced GABAergic Synaptic Transmission and Plasticity to Cholinergic Interneurons in the Nucleus Accumbens.Molecular neurobiology · 2023Article
- Synaptic effects of ethanol on striatal circuitry: therapeutic implications for dystonia.The FEBS journal · 2022Review
- The peripheral dopamine 2 receptor antagonist domperidone attenuates ethanol enhancement of dopamine levels in the nucleus accumbens.Alcoholism, clinical and experimental research · 2022Article
- Modulation of dopamine release by ethanol is mediated by atypical GABAAddiction biology · 2022Article
- Translational and Molecular Cytoarchitectural Genetic Guided Therapy to Induce Dopamine Homeostatic Neuro-signaling in Reward Deficiency and Associated Drug and Behavioral Addiction Seeking: A 60 Year Sojourn the Future is Now.EC psychology and psychiatry · 2021Article
- Bidirectional sex-dependent regulation of α6 and β3 nicotinic acetylcholine receptors by protein kinase Cε.Addiction biology · 2021Article
- Spontaneous Formation of Melanin from Dopamine in the Presence of Iron.Antioxidants (Basel, Switzerland) · 2020Article
- Corticotropin releasing factor, but not alcohol, modulates norepinephrine release in the rat central nucleus of the amygdala.Neuropharmacology · 2020Article
- Different adaptations of dopamine release in Nucleus Accumbens shell and core of individual alcohol drinking groups of mice.Neuropharmacology · 2020Article
- Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol.Neuropharmacology · 2019Article
- In vivo voltammetric evidence that locus coeruleus activation predominantly releases norepinephrine in the infralimbic cortex: Effect of acute ethanol.Synapse (New York, N.Y.) · 2019Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
Electrophysiology and microdialysis studies have provided compelling evidence that moderate to high ethanol concentrations enhance dopamine (DA) neurotransmission in the nucleus accumbens (NAc) through the mesolimbic DA system. However, with fast-scan cyclic voltammetry, short-term exposure to moderate to high doses of ethanol decreases evoked DA release at terminals in the NAc. The aim of this study was to evaluate the involvement of nicotinic acetylcholine receptors (nAChRs) in modulating the effects of ethanol on DA release in the NAc of C57BL/6 mice ex vivo and in vivo. Local stimulation evoked robust, frequency-dependent DA release in the NAc slice preparation, with maximal release at 40 Hz in the shell and 20 Hz in the core. Nicotine decreased DA release in a concentration-dependent (0.01-10 μM) manner in the shell and core, with an IC50 of 0.1 μM ex vivo and 0.5 mg/kg in vivo. Nicotine and ethanol inhibition of DA release was blocked by the α6*-nAChR antagonist α-conotoxins CtxMII and α-CtxMII [H9A; L15A] ex vivo (100 nM) in the core but not the shell. Furthermore, the nonspecific nAChR antagonist mecamylamine (2 mg/kg) blocked the effects of ethanol in the core in vivo. These findings suggest that DA release is inhibited by ethanol via nAChRs in the NAc and that DA modulation by nAChRs differs in the core versus the shell, with α6*-nAChRs affecting DA release in the core but not in the shell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.