Evidence map›Paper›PMID 24643636›Full record

Trial reportEuropean journal of clinical pharmacology2014

The effect of omega-3 fatty acids on depressive symptoms and inflammatory markers in maintenance hemodialysis patients: a randomized, placebo-controlled clinical trial.

Afshin Gharekhani, Mohammad-Reza Khatami, Simin Dashti-Khavidaki, Effat Razeghi, Ahmad-Ali Noorbala, Seyed-Saeed Hashemi-Nazari, Mohammad-Ali Mansournia

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  3. Omega-3 fatty acids for depression in adults.The Cochrane database of systematic reviews · 2021
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  7. Effects of Omega-3 Fatty Acids on Markers of Inflammation in Patients With Chronic Kidney Disease: A Controversial Issue.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2018
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  14. Omega-3 fatty acids for depression in adults.The Cochrane database of systematic reviews · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Afshin GharekhaniDepartment of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad-Reza Khatami
Simin Dashti-Khavidaki
Effat Razeghi
Ahmad-Ali Noorbala
Seyed-Saeed Hashemi-Nazari
Mohammad-Ali Mansournia

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study was designed to investigate the effects of omega-3 fatty acids on depression and chronic inflammation in hemodialysis patients.

methodFifty-four maintenance hemodialysis patients were randomized to ingest two omega-3 (each containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid) or placebo capsules, three times daily for 4 months.

main outcome measuresBeck Depression Inventory (BDI) score and serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, ferritin, intact parathyroid hormone (iPTH), and ratios of IL-10 to IL-6 and IL-10 to TNF-α were measured at baseline and at the end of the study.

resultsOmega-3 supplement lowered BDI score significantly after 4 months of intervention. Among pro- and anti-inflammatory mediators, only serum ferritin level and IL-10 to IL-6 ratio showed significant changes in favor of omega-3 supplement during the study. In linear regression model adjusted for baseline values, omega-3 treatment was a significant predictor of reduced serum CRP, ferritin, and iPTH levels, and increased IL-10 to IL-6 ratio. No significant association was found between the anti-inflammatory and anti-depressant effects of omega-3 supplement.

conclusionsSupplemental use of omega-3 fatty acids decreases depressive symptoms in hemodialysis patients apart from their anti-inflammatory effects.

Indexed as

Renal DialysisAnti-Inflammatory Agents, Non-SteroidalBiomarkersC-Reactive ProteinDepressionDietary SupplementsDrug Administration ScheduleDrug CombinationsFatty Acids, Omega-3FemaleHumansInterleukinsKidney Failure, ChronicMaleMiddle AgedSingle-Blind MethodAnti-Inflammatory Agents, Non-SteroidalBiomarkersC-Reactive ProteinDrug CombinationsFatty Acids, Omega-3InterleukinsTumor Necrosis Factor-alpha

Identifiers

PMID24643636

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.