ReviewJournal of assisted reproduction and genetics2014
Molecular mechanisms involved in varicocele-associated infertility.
Review in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 93 citations in OpenAlex.
- Observation or treatment of paediatric varicoceles: revisiting the evidence.Nature reviews. Urology · 2026Review
- Article
- N6-methyladenosine modification of PLOD2 causes spermatocyte damage in rats with varicocele.Cellular & molecular biology letters · 2023Article
- Effects of probiotic supplementation on semen parameters after varicocelectomy: A randomized controlled trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Article
- Influence of Risk Factors for Male Infertility on Sperm Protein Composition.International journal of molecular sciences · 2021Review
- Observational
- Protein Fingerprinting of Seminal Plasma Reveals Dysregulation of Exosome-Associated Proteins in Infertile Men with Unilateral Varicocele.The world journal of men's health · 2021Article
- Effects of HIF-1α on Spermatogenesis of Varicocele Rats by Regulating VEGF/PI3K/Akt Signaling Pathway.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Evaluation of testicular spermatogenic function by ultrasound elastography in patients with varicocele-associated infertility.American journal of translational research · 2021Article
- Seminal Plasma Analysis of Oxidative Stress in Different Genitourinary Topographical Regions Involved in Reproductive Tract Disorders Associated with Genital Heat Stress.International journal of molecular sciences · 2020Article
- Down regulating PHGDH affects the lactate production of sertoli cells in varicocele.Reproductive biology and endocrinology : RB&E · 2020Article
- Proteomic Analyses of Human Sperm Cells: Understanding the Role of Proteins and Molecular Pathways Affecting Male Reproductive Health.International journal of molecular sciences · 2020Review
- Varicocele Repair Prior to Assisted Reproductive Technology: Patient Selection and Special Considerations.Research and reports in urology · 2020Review
- GYY4137 a HIranian journal of basic medical sciences · 2019Article
- Role of varicocele treatment in assisted reproductive technologies.Arab journal of urology · 2018Review
- Semen parameters in men with varicocele: DNA fragmentation, chromatin packaging, mitochondrial membrane potential, and apoptosis.JBRA assisted reproduction · 2017Article
- Comparative Expression Analysis of HSP70, HSP90, IL-4, TNF, KITLG and KIT-receptor Gene between Varicocele-Induced and Non-Varicocele Testes of Dog.International journal of fertility & sterility · 2017Article
- The Role of Varicocele in Male Factor Subfertility.Current urology reports · 2017Review
- Varicoceles affect semen quality of infertile men in Southern China: A cross-sectional study of 5447 cases.Medicine · 2017Article
- Genetics and epigenetics of varicocele pathophysiology: an overview.Journal of assisted reproduction and genetics · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Varicocele is a pathologic enlargement of the pampiniform venous plexus within the spermatic cord, a condition that is a common cause of impaired sperm production and decreased quality of sperm. While varicocele is the most common surgically correctable risk factor for male infertility, not all males with varicocele experience infertility. In fact, most men with varicocele have normal spermatogenesis. Despite its prevalence, the molecular mechanisms of varicocele and its effect on testicular function are yet to be completely understood. We postulate that men with varicocele-associated infertility could have preexisting genetic lesions or defects in molecular mechanisms that make them more susceptible to varicocele-mediated testicular injury affecting spermatogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.