ArticleInfection and immunity2014
Type III secretion needle proteins induce cell signaling and cytokine secretion via Toll-like receptors.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Salmonellosis: An Overview of Epidemiology, Pathogenesis, and Innovative Approaches to Mitigate the Antimicrobial Resistant Infections.Antibiotics (Basel, Switzerland) · 2024Review
- Modulation of Inflammatory Signaling Molecules inVaccines · 2022Article
- Avian Macrophage Responses to Virulent and AvirulentPathogens (Basel, Switzerland) · 2022Article
- Salmonella Typhimurium and inflammation: a pathogen-centric affair.Nature reviews. Microbiology · 2021Review
- Critical Role for the NLRP3 Inflammasome in Mediating IL-1β Production inFrontiers in immunology · 2020Article
- Early Cytokine Induction UponFrontiers in immunology · 2020Article
- IL-27 amplifies cytokine responses to Gram-negative bacterial products and Salmonella typhimurium infection.Scientific reports · 2018Article
- Pig lacks functional NLRC4 and NAIP genes.Immunogenetics · 2017Article
- Bacterial secretion systems and regulation of inflammasome activation.Journal of leukocyte biology · 2017Review
- Interleukin-8, CXCL1, and MicroRNA miR-146a Responses to Probiotic Escherichia coli Nissle 1917 and Enteropathogenic E. coli in Human Intestinal Epithelial T84 and Monocytic THP-1 Cells after Apical or Basolateral Infection.Infection and immunity · 2016Article
- Yersinia versus host immunity: how a pathogen evades or triggers a protective response.Current opinion in microbiology · 2016Review
- The N terminus of type III secretion needle protein YscF from Yersinia pestis functions to modulate innate immune responses.Infection and immunity · 2015Article
- Yersinia pestis activates both IL-1β and IL-1 receptor antagonist to modulate lung inflammation during pneumonic plague.PLoS pathogens · 2015Article
- Interactions of Salmonella with animals and plants.Frontiers in microbiology · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogens are recognized by hosts by use of various receptors, including the Toll-like receptor (TLR) and Nod-like receptor (NLR) families. Ligands for these varied receptors, including bacterial products, are identified by the immune system, resulting in development of innate immune responses. Only a couple of components from type III secretion (T3S) systems are known to be recognized by TLR or NLR family members. Known T3S components that are detected by pattern recognition receptors (PRRs) are (i) flagellin, detected by TLR5 and NLRC4 (Ipaf); and (ii) T3S rod proteins (PrgJ and homologs) and needle proteins (PrgI and homologs), detected by NAIP and the NLRC4 inflammasome. In this report, we characterize the induction of proinflammatory responses through TLRs by the Yersinia pestis T3S needle protein, YscF, the Salmonella enterica needle proteins PrgI and SsaG, and the Shigella needle protein, MxiH. More specifically, we determine that the proinflammatory responses occur through TLR2 and -4. These data support the hypothesis that T3S needles have an unrecognized role in bacterial pathogenesis by modulating immune responses.
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Registered trials
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