ArticleJournal of biomedical optics2014
Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 42 citations in OpenAlex.
- Optical coherence tomography enables optical biopsy of endometrial tissue for early cancer detection.Npj imaging · 2026Article
- Convolutional neural network-based regression analysis to predict subnuclear chromatin organization from two-dimensional optical scattering signals.Journal of biomedical optics · 2024Article
- A Perspective Review: Analyzing Collagen Alterations in Ovarian Cancer by High-Resolution Optical Microscopy.Cancers · 2024Review
- Towards targeted colorectal cancer biopsy based on tissue morphology assessment by compression optical coherence elastography.Frontiers in oncology · 2023Article
- Skin cancer margin detection using nanosensitive optical coherence tomography and a comparative study with confocal microscopy.Biomedical optics express · 2022Article
- Estimation of porcine pancreas optical properties in the 600-1100 nm wavelength range for light-based therapies.Scientific reports · 2022Article
- Origins of subdiffractional contrast in optical coherence tomography.Biomedical optics express · 2021Article
- Assessment of internal refractive index profile of stochastically inhomogeneous nuclear models via analysis of two-dimensional optical scattering patterns.Journal of biomedical optics · 2021Article
- Diagnosing colorectal abnormalities using scattering coefficient maps acquired from optical coherence tomography.Journal of biophotonics · 2021Article
- Nanosensitive optical coherence tomography to assess wound healing within the cornea.Biomedical optics express · 2020Article
- Platform for quantitative multiscale imaging of tissue composition.Biomedical optics express · 2020Article
- Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring.Scientific reports · 2019Article
- Detection of Malignancy in Ocular Surface Lesions by Inverse Spectroscopic Optical Coherence Tomography and Two-Photon Autofluorescence.Translational vision science & technology · 2019Article
- Light scattering methods for tissue diagnosis.Optica · 2019Article
- Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging.Light, science & applications · 2019Article
- Identifying molecular contributors to autofluorescence of neoplastic and normal colon sections using excitation-scanning hyperspectral imaging.Journal of biomedical optics · 2018Article
- In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis.Optics letters · 2018Article
- Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography.Light, science & applications · 2018Article
- Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan.Scientific reports · 2017Article
- Measuring the Autocorrelation Function of Nanoscale Three-Dimensional Density Distribution in Individual Cells Using Scanning Transmission Electron Microscopy, Atomic Force Microscopy, and a New Deconvolution Algorithm.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2017Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolved optical and ultrastructural properties of the mucosa were quantified from histologically normal rectal biopsies from patients with and without colon adenomas (n=85) as well as from histologically normal peri-ampullary duodenal biopsies from patients with and without PC (n=22). Changes in the epithelium and stroma in CRC field carcinogenesis were separately quantified. In both compartments, optical and ultra-structural alterations were consistent. Optical alterations included lower backscattering (μb) and reduced scattering (μs') coefficients and higher anisotropy factor g. Ultrastructurally pronounced alterations were observed at length scales up to ∼450 nm, with the shape of the mass density correlation function having a higher shape factor D, thus implying a shift to larger length scales. Similar alterations were found in the PC field carcinogenesis despite the difference in genetic pathways and etiologies. We further verified that the chromatin clumping in epithelial cells and collagen cross-linking caused D to increase in vitro and could be among the mechanisms responsible for the observed changes in epithelium and stroma, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.