Evidence map›Paper›PMID 24643444›Full record

ArticleInternational journal of behavioral medicine2015

Examining associations between cognitive-affective vulnerability and HIV symptom severity, perceived barriers to treatment adherence, and viral load among HIV-positive adults.

Teresa M Leyro, Anka A Vujanovic, Marcel O Bonn-Miller

Registry-linked trialAbstract read
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In one paragraph

Article in International journal of behavioral medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06717581 (Variation in Drug Interactions in People With HIV), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06717581 recruitingnot on this mapstarted 2024, after this paper: background citation

Variation in Drug Interactions in People With HIV (PLWH) Aged 60 Years and Older on Stable Antiretroviral Therapy Making a Switch to Bictegravir/Tenofovir Alafenamide/Emtricitabine

TypeobservationalSponsorIRCCS Azienda Ospedaliero-Universitaria di BolognaRan2024 to 2025Enrolled50ConditionsHIV Infections, Drug Interaction, Elderly Infection, Comorbidities and Coexisting Conditions
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Review
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  13. Anxiety sensitivity in relation to sleep quality among HIV-infected individuals.The Journal of the Association of Nurses in AIDS Care : JANAC
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Teresa M LeyroDepartment of Psychology, Rutgers, The State University of New Jersey, Tillett Hall, 53 Avenue E, Piscataway, NJ, 08853, USA, Teresa.leyro@rutgers.edu.
Anka A Vujanovic
Marcel O Bonn-Miller

Funding

TREATMENTS FOR COMPLEX PATIENTS IN NEW SETTINGSP50DA009253 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WEISNER, CONSTANCE M. · 1994 to 2014
$28.2M
Substance Use Disorders Treatment/Services Research Training ProgramT32DA007250 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Derek D Satre, Janice Y Tsoh · 1991 to 2026
$7.4M
Center for Clinical and Translational Sciences (CCTS)KL2TR000370 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$4.3M
NCATS NIH HHS K12TR000370-07NIDA NIH HHS P50 DA009253NIDA NIH HHS T32 DA007250
6 · The paper itself

Abstract

backgroundLittle research on symptom impairment and quality of life among HIV-positive (HIV+) individuals has attended to the potential role of cognitive-affective vulnerabilities. Emerging research indicates that emotion regulation (ER), anxiety sensitivity (AS), and distress tolerance (DT) are associated with a range of mental health outcomes and demonstrate meaningful relations to clinical outcomes in HIV+ individuals. PURPOSE: In this investigation, we sought to concurrently examine these factors in relation HIV symptom severity, barriers to medication adherence, and disease viral load.

methodParticipants were 139 HIV+ individuals (34 female; age M = 48.2 years, SD = 8.1, 42% Black) receiving outpatient HIV care and prescribed at least one antiretroviral medication. We used hierarchical regression analyses to concurrently examine ER, AS, and DT in relation to severity of HIV symptoms, barriers to medication adherence, and disease viral load.

resultsAfter accounting for alcohol use problems, cannabis dependence, gender, and education, AS was significantly associated with HIV symptom severity (β = .35, p < .01) whereas ER evidenced a trend relation (β = .19, p = .07). ER (β = .45, p < .01), but not AS or DT, was significantly related to barriers to medication adherence, above and beyond variance accounted for by covariates. Finally, ER evidenced a trend level relation to viral load (β = .21, p = .07), above and beyond variance accounted for by cannabis use.

conclusionFindings provide an extension of previous research, suggesting unique roles of cognitive-affective vulnerabilities in terms of HIV symptom severity, medication use barriers, and infection symptomatology, and inform the refinement of current treatments for HIV+ individuals so as to improve functioning.

Indexed as

CognitionMedication AdherenceQuality of LifeAdultFemaleHIV InfectionsHumansMaleMiddle AgedPerceptionRegression AnalysisViral Load

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.