Evidence map›Paper›PMID 24643164›Full record

ArticleTranslational psychiatry2014

Glutamate/glutamine and neuronal integrity in adults with ADHD: a proton MRS study.

S Maltezos, J Horder, S Coghlan, C Skirrow, R O'Gorman, T J Lavender, M A Mendez, M Mehta, E Daly, K Xenitidis and 7 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04823364 (Measuring Glutamate and GABA Brain Levels in Adults With Attention Deficit Hyperactivity Disorder), which is not on this map. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04823364 naterminatednot on this mapstarted 2024, after this paper: background citation

Measuring Glutamate and GABA Brain Levels in Adults With Attention Deficit Hyperactivity Disorder (ADHD) Using Magnetic Resonance Spectroscopy (MRS)

TypeinterventionalSponsorWeizmann Institute of ScienceRan2024 to 2024Enrolled60ConditionsAttention Deficit Disorder With HyperactivityArmsNeurotransmitters evaluation by MRS
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 107 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

S Maltezos1] Adult ADHD Service, The Maudsley Hospital, London, UK [2] King's College London, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, London, UK.
J HorderKing's College London, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, London, UK.
S CoghlanKing's College London, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, London, UK.
C SkirrowKing's College London, MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
R O'GormanKing's College London, Department of Neuroimaging, Institute of Psychiatry, London, UK.
T J LavenderKing's College London, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, London, UK.
M A Mendez1] King's College London, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, London, UK [2] Autism Assessment and Behavioural Genetics Clinic, South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham, UK.
M MehtaKing's College London, Department of Neuroimaging, Institute of Psychiatry, London, UK.
E DalyKing's College London, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, London, UK.
K Xenitidis1] Adult ADHD Service, The Maudsley Hospital, London, UK [2] King's College London, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, London, UK.
E PaliokostaAdult ADHD Service, The Maudsley Hospital, London, UK.
D Spain1] King's College London, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, London, UK [2] Autism Assessment and Behavioural Genetics Clinic, South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham, UK.
M PittsAdult ADHD Service, The Maudsley Hospital, London, UK.
P Asherson1] Adult ADHD Service, The Maudsley Hospital, London, UK [2] King's College London, MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
D J LythgoeKing's College London, Department of Neuroimaging, Institute of Psychiatry, London, UK.
G J BarkerKing's College London, Department of Neuroimaging, Institute of Psychiatry, London, UK.ORCID 0000000252147421
D G Murphy1] King's College London, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, London, UK [2] Autism Assessment and Behavioural Genetics Clinic, South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham, UK [3] Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, King's College London, London, UK.
King's College London · GBMaudsley Hospital · GBSouth London and Maudsley NHS Foundation Trust · GB

Funding

Department of Health RP-PG-0606-1045Wellcome Trust
6 · The paper itself

Abstract

There is increasing evidence that abnormalities in glutamate signalling may contribute to the pathophysiology of attention-deficit hyperactivity disorder (ADHD). Proton magnetic resonance spectroscopy ([1H]MRS) can be used to measure glutamate, and also its metabolite glutamine, in vivo. However, few studies have investigated glutamate in the brain of adults with ADHD naive to stimulant medication. Therefore, we used [1H]MRS to measure the combined signal of glutamate and glutamine (Glu+Gln; abbreviated as Glx) along with other neurometabolites such as creatine (Cr), N-acetylaspartate (NAA) and choline. Data were acquired from three brain regions, including two implicated in ADHD-the basal ganglia (caudate/striatum) and the dorsolateral prefrontal cortex (DLPFC)-and one 'control' region-the medial parietal cortex. We compared 40 adults with ADHD, of whom 24 were naive for ADHD medication, whereas 16 were currently on stimulants, against 20 age, sex and IQ-matched healthy controls. We found that compared with controls, adult ADHD participants had a significantly lower concentration of Glx, Cr and NAA in the basal ganglia and Cr in the DLPFC, after correction for multiple comparisons. There were no differences between stimulant-treated and treatment-naive ADHD participants. In people with untreated ADHD, lower basal ganglia Glx was significantly associated with more severe symptoms of inattention. There were no significant differences in the parietal 'control' region. We suggest that subcortical glutamate and glutamine have a modulatory role in ADHD adults; and that differences in glutamate-glutamine levels are not explained by use of stimulant medication.

Indexed as

AdultAttention Deficit Disorder with HyperactivityBasal GangliaGlutamic AcidGlutamineHumansMagnetic Resonance SpectroscopyPrefrontal CortexGlutamic AcidGlutamine

Identifiers

PMID24643164
PMCPMC3966039
OpenAlexW2083331867

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.