Evidence map›Paper›PMID 24643081›Full record

Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2014

Cerebral hemodynamics in normal aging: central artery stiffness, wave reflection, and pressure pulsatility.

Takashi Tarumi, Muhammad Ayaz Khan, Jie Liu, Benjamin Y Tseng, Benjamin M Tseng, Rosemary Parker, Jonathan Riley, Cynthia Tinajero, Rong Zhang

Erratum issuedOpen access · bronzeAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 128 papers.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 207 citations in OpenAlex.

  1. Trial
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  5. Effect of age and vascular anatomy on blood flow in major cerebral vessels.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015
    Trial
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  8. Review
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68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
    Tseng, Benjamin M [corrected to Tseng, Benjamin Y]
5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Takashi Tarumi1] Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA [2] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Muhammad Ayaz Khan1] Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA [2] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jie Liu1] Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA [2] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Benjamin Y Tseng1] Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA [2] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Benjamin M Tseng1] Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA [2] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Rosemary ParkerInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Jonathan RileyInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Cynthia TinajeroInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Rong Zhang1] Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA [2] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Institute for Exercise and Environmental Medicine · USPresbyterian Hospital · USThe University of Texas Southwestern Medical Center · US

Funding

Mild Cognitive Impairment: Cerebrovascular Dysfunction and Exercise TrainingR01AG033106 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG, ZHANG, RONG · 2009 to 2012
$3.1M
Arterial Aging, Brain Perfusion & Exercise: Impact on Brain Structure & Function.R01HL102457 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, RONG · 2010 to 2013
$2.1M
NHLBI NIH HHS R01 HL102457NHLBI NIH HHS R01HL102457-01NIA NIH HHS R01 AG033106NIA NIH HHS R01AG033106-01
6 · The paper itself

Abstract

Blood ejected from the left ventricle perfuses the brain via central elastic arteries, which stiffen with advancing age and may elevate the risk of end-organ damage. The purpose of this study was to determine the impact of central arterial aging on cerebral hemodynamics. Eighty-three healthy participants aged 22 to 80 years underwent the measurements of cerebral blood flow (CBF) and CBF velocity (CBFV) using magnetic resonance imaging (MRI) and transcranial Doppler, respectively. The CBF pulsatility was determined by the relative amplitude of CBFV to the mean value (CBFV%). Central arterial stiffness (carotid-femoral pulse wave velocity), wave reflection (carotid augmentation index), and pressure were measured using applanation tonometry. Total volume of white-matter hyperintensity (WMH) was quantified from MR images. Total CBF decreased with age while systolic and pulsatile CBFV% increased and diastolic CBFV% decreased. Women showed greater total CBF and lower cerebrovascular resistance than men. Diastolic CBFV% was lower in women than in men. Age- and sex-related differences in CBF pulsatility were independently associated with carotid pulse pressure and arterial wave reflection. In older participants, higher pulsatility of CBF was associated with the greater total volume of WMH. These findings indicate that central arterial aging has an important role in age-related differences in cerebral hemodynamics.

Indexed as

Blood Flow VelocityCerebrovascular CirculationMagnetic Resonance AngiographyPulsatile FlowSex CharacteristicsVascular StiffnessAdultAgedAgingFemaleHumansMaleMiddle Aged

Identifiers

PMID24643081
PMCPMC4050241
OpenAlexW2059969387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.