ArticlePloS one2014
relA enhances the adherence of enteropathogenic Escherichia coli.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Mutating bothFrontiers in microbiology · 2023Article
- Pathophysiology of enteropathogenicJournal of veterinary science · 2022Review
- Diversity inFrontiers in microbiology · 2020Review
- Phosphate uptake by the phosphonate transport system PhnCDE.BMC microbiology · 2019Article
- Glyphosate induces the synthesis of ppGpp.Molecular genetics and genomics : MGG · 2019Article
- Mechanisms underlying the virulence regulation of newEmerging microbes & infections · 2019Article
- Environment Controls LEE Regulation in EnteropathogenicFrontiers in microbiology · 2018Review
- ppGpp and cytotoxicity diversity in Shiga toxin-producing Escherichia coli (STEC) isolates.Epidemiology and infection · 2017Article
- Differential regulation of polyphosphate genes in Pseudomonas aeruginosa.Molecular genetics and genomics : MGG · 2017Article
- Article
- Finding Regulators Associated with the Expression of the Long Polar Fimbriae in Enteropathogenic Escherichia coli.Journal of bacteriology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enteropathogenic Escherichia coli (EPEC) is a known causative agent of diarrhea in children. In the process of colonization of the small intestine, EPEC synthesizes two types of adhesins, the bundle-forming pilus (BFP) and intimin. The BFP pilus is an adhesin associated with the initial stages of adherence of EPEC to epithelial cells, while the outer membrane protein intimin carries out the intimate adherence that takes place at the third stage of infection. BFP is encoded by the bfp operon located in plasmid EAF, present only in typical EPEC isolates, while eae, the gene that encodes intimin is situated in the LEE, a chromosomal pathogenicity island. Transcription of bfp and eae is regulated by the products of the perABC operon, also present in plasmid EAF. Here we show that deletion of relA, that encodes a guanosine penta and tetraphosphate synthetase impairs EPEC adherence to epithelial cells in vitro. In the absence of relA, the transcription of the regulatory operon perABC is reduced, resulting in lower levels of BFP and intimin. Bacterial adherence, BFP and intimin synthesis and perABC expression are restored upon complementation with the wild-type relA allele.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.