ArticleScientific reports2014
Genome wide identification of fruitless targets suggests a role in upregulating genes important for neural circuit formation.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 43 citations in OpenAlex.
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- Social experience and pheromone receptor activity reprogram gene expression in sensory neurons.G3 (Bethesda, Md.) · 2023Article
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- Sex-biased expression is associated with chromatin state inbioRxiv : the preprint server for biology · 2023Article
- Molecular and cellular origins of behavioral sex differences: a tiny little fly tells a lot.Frontiers in molecular neuroscience · 2023Review
- Interplay between sex determination cascade and major signaling pathways during Drosophila eye development: Perspectives for future research.Developmental biology · 2021Review
- A non-coding indel polymorphism in theProceedings. Biological sciences · 2021Article
- Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior.PLoS genetics · 2021Article
- A sex-specific switch between visual and olfactory inputs underlies adaptive sex differences in behavior.Current biology : CB · 2021Article
- Investigation ofeLife · 2021Article
- Fruitless decommissions regulatory elements to implement cell-type-specific neuronal masculinization.PLoS genetics · 2021Article
- Distinct Roles and Synergistic Function of FruCell reports · 2020Article
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- Layered roles ofeLife · 2020Article
- The mode of action of Fruitless: Is it an easy matter to switch the sex?Genes, brain, and behavior · 2020Review
- The Genetics of Male Pheromone Preference Difference BetweenG3 (Bethesda, Md.) · 2020Article
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Authors and funding
1 author at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fruitless gene (fru) encodes a set of transcription factors (Fru) that display sexually dimorphic gene expression in the brain of the fruit-fly; Drosophila melanogaster. Behavioural studies have demonstrated that fru is essential for courtship behaviour in the male fly and is thought to act by directing the development of sex-specific neural circuitry that encodes this innate behavioural response. This study reports the identification of direct regulatory targets of the sexually dimorphic isoforms of the Fru protein using an in vitro model system. Genome wide binding sites were identified for each of the isoforms using Chromatin Immunoprecipitation coupled to deep sequencing (ChIP-Seq). Putative target genes were found to be involved in processes such as neurotransmission, ion-channel signalling and neuron development. All isoforms showed a significant bias towards genes located on the X-chromosome, which may reflect a specific role for Fru in regulating x-linked genes. Taken together with expression analysis carried out in Fru positive neurons specifically isolated from the male fly brain, it appears that the Fru protein acts as a transcriptional activator. Understanding the regulatory cascades induced by Fru will help to shed light on the molecular mechanisms that are important for specification of neural circuitry underlying complex behaviour.
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