Evidence map›Paper›PMID 24642909›Full record

ArticleMolecules (Basel, Switzerland)2014

Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis.

Baskar Nammalwar, N Prasad Muddala, Christina R Bourne, Mary Henry, Philip C Bourne, Richard A Bunce, Esther W Barrow, K Darrell Berlin, William W Barrow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Baskar NammalwarDepartment of Chemistry, Oklahoma State University, 107 Physical Sciences, Stillwater, OK 74078, USA. baskar@okstate.edu.
N Prasad MuddalaDepartment of Chemistry, Oklahoma State University, 107 Physical Sciences, Stillwater, OK 74078, USA. muddala@okstate.edu.
Christina R BourneDepartment of Veterinary Pathobiology, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA. cbourne@ou.edu.
Mary HenryDepartment of Veterinary Pathobiology, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA. henrym@okstate.edu.
Philip C BourneDepartment of Veterinary Pathobiology, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA. pcbourne@yahoo.com.
Richard A BunceDepartment of Chemistry, Oklahoma State University, 107 Physical Sciences, Stillwater, OK 74078, USA. rab@okstate.edu.
Esther W BarrowDepartment of Veterinary Pathobiology, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA. esther.barrow@okstate.edu.
K Darrell BerlinDepartment of Chemistry, Oklahoma State University, 107 Physical Sciences, Stillwater, OK 74078, USA. kdb@okstate.edu.
William W BarrowDepartment of Veterinary Pathobiology, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA. bill.barrow@okstate.edu.

Funding

Broad-spectrum Antifolates for Treatment of Drug Resistant Bacillus anthracisR01AI090685 · NIAID · OKLAHOMA STATE UNIVERSITY STILLWATER · PI BUNCE, RICHARD A · 2010 to 2014
$3.9M
NIAID NIH HHS R01 AI090685NIAID NIH HHS R01-AI090685
6 · The paper itself

Abstract

Due to the innate ability of bacteria to develop resistance to available antibiotics, there is a critical need to develop new agents to treat more resilient strains. As a continuation of our research in this area, we have synthesized a series of racemic 2,4-diaminopyrimidine-based drug candidates, and evaluated them against Bacillus anthracis. The structures are comprised of a 2,4-diaminopyrimidine ring, a 3,4-dimethoxybenzyl ring, and an N-acryloyl-substituted 1,2-dihydrophthalazine ring. Various changes were made at the C1 stereocenter of the dihydrophthalazine moiety in the structure, and the biological activity was assessed by measurement of the MIC and K(i) values to identify the most potent drug candidate.

Indexed as

Bacillus anthracisBinding SitesFolic Acid AntagonistsMicrobial Sensitivity TestsModels, MolecularMolecular ConformationProtein BindingPyrimidinesTetrahydrofolate Dehydrogenase2,4-diaminopyrimidineFolic Acid AntagonistsPyrimidinesTetrahydrofolate Dehydrogenase

Identifiers

PMID24642909
PMCPMC4016962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.