ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adherence to the Mediterranean diet and its protective effects against colorectal cancer: a meta-analysis of 26 studies with 2,217,404 participants.GeroScience · 2025Pooled it
- Oral Administration of Liposomal Resveratrol for Wound Healing in a Zebrafish Model.Molecules (Basel, Switzerland) · 2026Article
- Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein.Nutrients · 2025Review
- Modulation of Nrf2 and Mitochondrial Function: Pharmacological Implications.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.GeroScience · 2025Review
- Nanotech meets antibiotics: nucleotide antibiotics delivered by lipid nanoparticles.Frontiers in cellular and infection microbiology · 2025Review
- The Cognitive Restoration Effects of Resveratrol: Insight Molecular through Behavioral Studies in Various Cognitive Impairment Models.ACS pharmacology & translational science · 2024Review
- Article
- Nanocarriers for natural polyphenol senotherapeutics.Aging cell · 2024Review
- Article
- Review
- Biological function of resveratrol and its application in animal production: a review.Journal of animal science and biotechnology · 2023Review
- The untapped potential of targeting NRF2 in neurodegenerative disease.Frontiers in aging · 2023Article
- NADJournal of lipid and atherosclerosis · 2022Review
- Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.GeroScience · 2022Article
- Resveratrol ameliorates oxidative stress, inflammatory response and lipid metabolism in common carp (Frontiers in immunology · 2022Article
- pH-sensitive dual drug loaded janus nanoparticles by oral delivery for multimodal analgesia.Journal of nanobiotechnology · 2021Article
- Increased cognitive workload evokes greater neurovascular coupling responses in healthy young adults.PloS one · 2021Article
- Synthesized chrysin-loaded nanoliposomes improves cadmium-induced toxicity in mice.Environmental science and pollution research international · 2020Article
- Accessing Intracellular Targets through Nanocarrier-Mediated Cytosolic Protein Delivery.Trends in pharmacological sciences · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Resveratrol (3,4',5-trihydroxystilbene) is a plant-derived polyphenolic trans-stilbenoid, which exerts multifaceted antiaging effects. Here, we propose a novel delivery system for resveratrol, which significantly increases its cellular uptake into aged cells. Combination of resveratrol with a positively charged lipid component to "conventional" liposomes converts these lipid vesicles to a robust fusogenic system. To study their cellular uptake and cellular effects, we treated primary cerebromicrovascular endothelial cells isolated from aged F344xBN rats with resveratrol encapsulated in fusogenic liposomes (FL-RSV). To demonstrate effective cellular uptake of FL-RSV, accumulation of the lipophilic tracer dye, DiR, and resveratrol in cerebromicrovascular endothelial cells was confirmed using flow cytometry and confocal microscopy and high-performance liquid chromatography electrochemical detection. Treatment of aged cerebromicrovascular endothelial cells with FL-RSV activated Nrf2 (assessed with a reporter gene assay), significantly decreased cellular production of reactive oxygen species (assessed by a flow cytometry-based H2DCFDA fluorescence method), and inhibited apoptosis. Taken together, encapsulation of resveratrol into novel fusogenic liposomes significantly enhances the delivery of resveratrol into aged cells, which subsequently results in rapid activation of cellular Nrf2-driven antioxidant defense mechanisms. Our studies provide proof-of-concept for the development of a novel, translationally relevant interventional strategy for prevention and/or control of oxidative stress-related pathophysiological conditions in aging.
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