Evidence map›Paper›PMID 24642786›Full record

ArticleEuropean journal of clinical nutrition2014

Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations.

S Santos, A Oliveira, C Pinho, S Casal, C Lopes

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Article in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

S SantosInstitute of Public Health, University of Porto, Porto, Portugal.
A Oliveira1] Institute of Public Health, University of Porto, Porto, Portugal [2] Department of Clinical Epidemiology, Predictive Medicine and Public Health and Cardiovascular Research and Development Unit, University of Porto Medical School, Porto, Portugal.
C PinhoREQUIMTE, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy, University of Porto, Porto, Portugal.
S Casal1] Institute of Public Health, University of Porto, Porto, Portugal [2] REQUIMTE, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy, University of Porto, Porto, Portugal.
C Lopes1] Institute of Public Health, University of Porto, Porto, Portugal [2] Department of Clinical Epidemiology, Predictive Medicine and Public Health and Cardiovascular Research and Development Unit, University of Porto Medical School, Porto, Portugal.
Universidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesEvidence on the association between fatty acids and adiponectin and leptin concentrations is scarce and inconsistent, which may in part be due to limitations of dietary reporting methods. We aimed to estimate the association of fatty acids, derived from a food frequency questionnaire (FFQ) and measured in the erythrocyte membrane, with adiponectin and leptin concentrations. SUBJECTS/

methodsWe studied 330 non-institutionalized inhabitants of Porto (52.4% women; age range: 26-64 years) evaluated in 2010-2011, as part of the EPIPorto cohort study. Fatty acids were derived from a validated semiquantitative FFQ and measured in the erythrocyte membrane by gas chromatography. Serum concentrations of adiponectin and leptin were determined through radioimmunoassay. Regression coefficients (β) and 95% confidence intervals (95% CI) were obtained from linear regression models, after controlling for gender, age, education, leisure time physical activity and total body fat percentage (obtained from dual energy X-ray absorptiometry).

resultsFatty acids measured by FFQ showed no significant associations with both adipokines. Lauric and linoleic acids, measured in the erythrocyte membrane, were significantly and positively associated with adiponectin (β=0.292, 95% CI: 0.168-0.416; β=0.150, 95% CI: 0.020-0.280) and leptin (β=0.071, 95% CI: 0.003-0.138; β=0.071, 95% CI: 0.002-0.140), whereas total n-3, eicosapentaenoic and docosahexaenoic acids were significantly but negatively associated with adiponectin (β=-0.289, 95% CI: -0.420 to -0.159; β=-0.174, 95% CI -0.307 to -0.040; β=-0.253, 95% CI -0.383 to -0.124) and leptin (β=-0.151, 95% CI: -0.220 to -0.083; β=-0.080, 95% CI: -0.151 to -0.009; β=-0.146, 95% CI: -0.214 to -0.078). Positive significant associations of palmitic and trans-fatty acids with adiponectin were also observed.

conclusionsA positive association of lauric and linoleic acids and a negative association of total n-3 fatty acids with both adipokines were observed only with fatty acids measured in the erythrocyte membrane.

Indexed as

Surveys and QuestionnairesAbsorptiometry, PhotonAdiponectinAdultCross-Sectional StudiesDietDietary FatsDocosahexaenoic AcidsEicosapentaenoic AcidErythrocyte MembraneFatty AcidsFemaleHumansLauric AcidsLeptinLinear ModelsAdiponectinDietary FatsDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acidslauric acidLauric AcidsLeptinLinoleic AcidTrans Fatty AcidsTriglycerides

Identifiers

PMID24642786
OpenAlexW2044965930

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.