ArticlePloS one2014
Haematological reference intervals in a multiethnic population.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta.Frontiers in immunology · 2021Trial
- Defining Reference Intervals for Complete Blood Count and Micronutrient Parameters in Urban Bangladeshi Population.Biomolecules · 2026Article
- Comparison of the diagnostic performance of machine learning algorithms for differentiating iron deficiency anemia and thalassemia.Annals of hematology · 2026Article
- A Machine Learning Approach to Reference Interval Estimation for Red Cell Parameters in a South and East Asian Population.Annals of laboratory medicine · 2026Article
- Machine learning approach for differentiating iron deficiency anemia and thalassemia using random forest and gradient boosting algorithms.Scientific reports · 2025Article
- Gender Differences in Clinical and Biochemical Variables of Patients Affected by Bipolar Disorder.Brain sciences · 2025Article
- Common Hematological Reference Indices Among Healthy Reproductive Age Indian Women-Data Subset from Nationwide Study.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024Article
- Derivation of Russian-specific reference intervals for complete blood count, iron markers and related vitamins.PloS one · 2024Article
- Establishing reference intervals for common hematology test parameters from apparently healthy geriatrics in Asella town, Southeast Ethiopia, 2020: a community-based cross-sectional study.Frontiers in medicine · 2024Article
- Hematological indices in the adult saudi population: Reference intervals by gender, age, and region.Frontiers in medicine · 2022Article
- A Novel Algorithm Using Cell Population Data (VCS Parameters) as a Screening Discriminant between Alpha and Beta Thalassemia Traits.Diagnostics (Basel, Switzerland) · 2021Article
- Neoteric Algorithm Using Cell Population Data (VCS Parameters) as a Rapid Screening Tool for Haematological Disorders.Diagnostics (Basel, Switzerland) · 2021Article
- Reference intervals of red blood cell parameters and platelet count for healthy adults in Japan.International journal of hematology · 2021Article
- Cancer incidence following a high-normal platelet count: cohort study using electronic healthcare records from English primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020Article
- CALIPER Hematology Reference Standards (II).American journal of clinical pathology · 2020Article
- ThalPred: a web-based prediction tool for discriminating thalassemia trait and iron deficiency anemia.BMC medical informatics and decision making · 2019Article
- The significance of serum HMGB1 level in humans with acute paraquat poisoning.Scientific reports · 2019Observational
- [Anemia in the aged].Zeitschrift fur Gerontologie und Geriatrie · 2018Article
- Complete Blood Count Reference Intervals and Patterns of Changes Across Pediatric, Adult, and Geriatric Ages in Korea.Annals of laboratory medicine · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSimilar to other populations, full blood count reference (FBC) intervals in Malaysia are generally derived from non-Malaysian subjects. However, numerous studies have shown significant differences between and within populations supporting the need for population specific intervals.
methodsTwo thousand seven hundred twenty five apparently healthy adults comprising all ages, both genders and three principal races were recruited through voluntary participation. FBC was performed on two analysers, Sysmex XE-5000 and Unicel DxH 800, in addition to blood smears and haemoglobin analysis. Serum ferritin, soluble transferrin receptor and C-reactive protein assays were performed in selected subjects. All parameters of qualified subjects were tested for normality followed by determination of reference intervals, measures of central tendency and dispersion along with point estimates for each subgroup.
resultsComplete data was available in 2440 subjects of whom 56% (907 women and 469 men) were included in reference interval calculation. Compared to other populations there were significant differences for haemoglobin, red blood cell count, platelet count and haematocrit in Malaysians. There were differences between men and women, and between younger and older men; unlike in other populations, haemoglobin was similar in younger and older women. However ethnicity and smoking had little impact. 70% of anemia in premenopausal women, 24% in postmenopausal women and 20% of males is attributable to iron deficiency. There was excellent correlation between Sysmex XE-5000 and Unicel DxH 800.
conclusionOur data confirms the importance of population specific haematological parameters and supports the need for local guidelines rather than adoption of generalised reference intervals and cut-offs.
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