Evidence map›Paper›PMID 24642524›Full record

ReviewNeuro-oncology2014

GBM's multifaceted landscape: highlighting regional and microenvironmental heterogeneity.

Alenoush Vartanian, Sanjay K Singh, Sameer Agnihotri, Shahrzad Jalali, Kelly Burrell, Kenneth D Aldape, Gelareh Zadeh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Potential therapeutic targeting of BKMolecular oncology · 2026
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alenoush VartanianThe Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (A.V., S.K.S., S.A., S.J., K.B., G.Z.); Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (G.Z.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.D.A.).
Sanjay K SinghThe Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (A.V., S.K.S., S.A., S.J., K.B., G.Z.); Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (G.Z.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.D.A.).
Sameer AgnihotriThe Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (A.V., S.K.S., S.A., S.J., K.B., G.Z.); Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (G.Z.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.D.A.).
Shahrzad JalaliThe Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (A.V., S.K.S., S.A., S.J., K.B., G.Z.); Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (G.Z.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.D.A.).
Kelly BurrellThe Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (A.V., S.K.S., S.A., S.J., K.B., G.Z.); Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (G.Z.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.D.A.).
Kenneth D AldapeThe Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (A.V., S.K.S., S.A., S.J., K.B., G.Z.); Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (G.Z.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.D.A.).
Gelareh ZadehThe Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (A.V., S.K.S., S.A., S.J., K.B., G.Z.); Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (G.Z.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.D.A.).

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

Gliomas are a heterogeneous group of tumors that show variable proliferative potential, invasiveness, aggressiveness, histological grading, and clinical behavior. In this review, we focus on glioblastoma multiforme (GBM), a grade IV glioma, which is the most common and malignant of primary adult brain tumors. Research over the past several decades has revealed the existence of extensive cellular, molecular, genetic, epigenetic, and metabolic heterogeneity among tumors of the same grade and even within individual tumors. Evaluation of different tumor types has shown that tumors with advanced grade and clinical aggressiveness also display enhanced molecular, cellular, and microenvironmental heterogeneity. From a therapeutic standpoint, this heterogeneity is a major clinical hurdle for devising effective therapeutic strategies for patients and challenges personalized medicine. In this review, we will highlight key aspects of GBM heterogeneity, directing special attention to regional heterogeneity, hypoxia, genomic heterogeneity, tumor-specific metabolic reprogramming, neovascularization or angiogenesis, and stromal immune cells. We will further discuss the clinical implications of GBM heterogeneity in the context of therapy.

Indexed as

Tumor MicroenvironmentAdultBrainBrain NeoplasmsCell ProliferationGlioblastomaHumansHypoxia, BrainNeovascularization, Pathologicangiogenesisglioblastomahypoxiametabolism

Identifiers

PMID24642524
PMCPMC4136895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.