ArticleThe Journal of clinical investigation2014
Nav-igating through a complex landscape: SCN10A and cardiac conduction.
Article in The Journal of clinical investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Voltage-gated sodium channel, Nav 1.8, regulates calcium dynamics in the dorsal root ganglion induced by cold nociceptive stimulus.PloS one · 2026Article
- Characterization of novel arrhythmogenic patterns arising secondary to heterogeneous expression and activation of Nav1.8.Frontiers in cardiovascular medicine · 2025Article
- Whole-exome sequencing uncovers the genetic complexity of bicuspid aortic valve in families with early-onset complications.American journal of human genetics · 2024Article
- Whole Exome Sequencing Uncovers the Genetic Complexity of Bicuspid Aortic Valve in Families with Early Onset Complications.medRxiv : the preprint server for health sciences · 2024Article
- Atrioventricular node dysfunction in pressure overload-induced heart failure-Involvement of the immune system and transcriptomic remodelling.Frontiers in pharmacology · 2023Article
- Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases.Cardiovascular research · 2020Article
- MultipleProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Deleterious protein-altering mutations in the SCN10A voltage-gated sodium channel gene are associated with prolonged QT.Clinical genetics · 2018Article
- Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart.Journal of the American Heart Association · 2016Article
- Inhibitory effects of neferine on Nav1.5 channels expressed in HEK293 cells.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Article
- SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes.Pflugers Archiv : European journal of physiology · 2015Article
- Isolation and characterization of embryonic stem cell-derived cardiac Purkinje cells.Stem cells (Dayton, Ohio) · 2015Article
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2 authors at 1 institution in 1 country.
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Abstract
Genome-wide association studies (GWAS) have implicated SCN10A, which encodes a nociceptor-associated voltage-gated sodium channel subunit, as a modulator of cardiac conduction; however, this role has traditionally been ascribed to SCN5A, which is highly expressed in cardiac muscle. SCN10A is believed to affect cardiac conduction either directly through cardiomyocytes or indirectly via intracardiac neurons. In this issue of the JCI, van den Boogaard and colleagues introduce a third possibility: that the SCN10A locus acts as an enhancer of SCN5A gene expression. The authors demonstrate that SCN10A expression is negligible within human and murine hearts, and that a T-box enhancer within the SCN10A locus drives SCN5A expression within cardiomyocytes. This work reasserts SCN5A as the key determinant of cardiac conduction and highlights the importance of deciphering the functionality of coding versus noncoding regions when interpreting GWAS data.
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