ArticleeLife2014
Molecular insights into the origin of the Hox-TALE patterning system.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- PfTALE5 Acts as a hub for multi-stress resilience: a genome-wide study of the TALE family in Paulownia fortunei.BMC plant biology · 2026Article
- Do the "big four" orders of insects comprise evolutionarily significant higher taxa with coherent patterns of selection on protein-coding genes?Evolution letters · 2025Article
- Identification and expression analysis of TALE superfamily genes explore their key roles in response to abiotic stress in Brassica napus.BMC plant biology · 2024Article
- Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator.eLife · 2024Article
- Topological structures and syntenic conservation in sea anemone genomes.Nature communications · 2023Article
- Spatial transcriptomics reveals a conserved segment polarity program that governs muscle patterning inbioRxiv : the preprint server for biology · 2023Article
- HOX Protein Activity Regulation by Cellular Localization.Journal of developmental biology · 2021Review
- Direct Molecular Evidence for an Ancient, Conserved Developmental Toolkit Controlling Posttranscriptional Gene Regulation in Land Plants.Molecular biology and evolution · 2021Article
- Genome-Wide Binding Analyses of HOXB1 Revealed a Novel DNA Binding Motif Associated with Gene Repression.Journal of developmental biology · 2021Article
- Article
- New roles for Wnt and BMP signaling in neural anteroposterior patterning.EMBO reports · 2019Article
- A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates.Nature communications · 2019Article
- Common ancestry of heterodimerizing TALE homeobox transcription factors across Metazoa and Archaeplastida.BMC biology · 2018Article
- Comprehensive Genome-Wide Classification Reveals That Many Plant-Specific Transcription Factors Evolved in Streptophyte Algae.Genome biology and evolution · 2017Article
- Non-model model organisms.BMC biology · 2017Article
- The cellular and molecular basis of cnidarian neurogenesis.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- A unique stylopod patterning mechanism by Shox2-controlled osteogenesis.Development (Cambridge, England) · 2016Article
- The Unicellular Ancestry of Groucho-Mediated Repression and the Origins of Metazoan Transcription Factors.Genome biology and evolution · 2016Article
- Mechanisms of Specificity for Hox Factor Activity.Journal of developmental biology · 2016Article
- Homeodomain proteins: an update.Chromosoma · 2016Review
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8 authors.
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Abstract
Despite tremendous body form diversity in nature, bilaterian animals share common sets of developmental genes that display conserved expression patterns in the embryo. Among them are the Hox genes, which define different identities along the anterior-posterior axis. Hox proteins exert their function by interaction with TALE transcription factors. Hox and TALE members are also present in some but not all non-bilaterian phyla, raising the question of how Hox-TALE interactions evolved to provide positional information. By using proteins from unicellular and multicellular lineages, we showed that these networks emerged from an ancestral generic motif present in Hox and other related protein families. Interestingly, Hox-TALE networks experienced additional and extensive molecular innovations that were likely crucial for differentiating Hox functions along body plans. Together our results highlight how homeobox gene families evolved during eukaryote evolution to eventually constitute a major patterning system in Eumetazoans. DOI: http://dx.doi.org/10.7554/eLife.01939.001.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.