Observational studyScandinavian journal of trauma, resuscitation and emergency medicine2014
The role of cell-free DNA measured by a fluorescent test in the management of isolated traumatic head injuries.
Observational study in Scandinavian journal of trauma, resuscitation and emergency medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Targeting NETosis in Acute Brain Injury: A Systematic Review of Preclinical and Clinical Evidence.Cells · 2024Pooled it
- The role of total cell-free DNA in predicting outcomes among trauma patients in the intensive care unit: a systematic review.Critical care (London, England) · 2017Pooled it
- Day One Cell-Free DNA Levels as an Objective Prognostic Marker of Mortality in Major Burns Patients.Cells · 2025Article
- Inflammaging, cellular senescence, and cognitive aging after traumatic brain injury.Neurobiology of disease · 2023Review
- The Citrullination-Neutrophil Extracellular Trap Axis in Chronic Diseases.Journal of innate immunity · 2022Review
- A prospective cohort study of dynamic cell-free DNA elevation during cardiac surgery with cardiopulmonary bypass.PloS one · 2022Article
- Traumatic injury is associated with reduced deoxyribonuclease activity and dysregulation of the actin scavenging system.Burns & trauma · 2021Article
- Cellular Senescence in Traumatic Brain Injury: Evidence and Perspectives.Frontiers in aging neuroscience · 2021Review
- Biological variability of cell-free DNA in healthy females at rest within a short time course.International journal of legal medicine · 2020Article
- Comparison of the source and prognostic utility of cfDNA in trauma and sepsis.Intensive care medicine experimental · 2019Article
- Article
- Quantitative analysis of individual cell-free DNA concentration before and after penetrating trauma.International journal of legal medicine · 2019Article
- Translating biomarkers from research to clinical use in pediatric neurocritical care: focus on traumatic brain injury and cardiac arrest.Current opinion in pediatrics · 2017Review
- Editorial: facts, figures and the future.Scandinavian journal of trauma, resuscitation and emergency medicine · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTraumatic brain injury (TBI) is a major cause of death and disability. In this study a new method to measure cell free DNA (CFD) for the management of TBI is tested. Our hypothesis was that CFD concentrations correlate to the magnitude of brain damage, and may predict the outcome of injured patients.
methodsTwenty eight patients with isolated head injury were enrolled. Their demographic and clinical data were recorded. CFD levels were determined in patients' sera samples by a direct fluorescence method developed in our laboratory.
resultsMean admission CFD values were lower in patients with mild TBI compared to severe injury (760 ± 340 ng/ml vs. 1600 ± 2100 ng/ml, p = 0.03), and in patients with complete recovery upon discharge compared to patients with disabilities (680 ± 260 ng/ml vs. 2000 ± 2300 ng/ml, p = 0.003). Patients with high CFD values had a relative risk to require surgery of 1.5 (95% CI 0.83 to 2.9) a relative risk to have impaired outcome on discharge of 2.8 (95% CI 0.75 - 10), and a longer length of stay (12 ± 13 days vs. 3.4 ± 4.8 days, p = 0.02). CFD values did not correlate with CT scan based grading.
conclusionsCFD levels may be used as a marker to assess the severity of TBI and to predict the prognosis. Its use should be considered as an additional tool along with currently used methods or as a surrogate for them in limited resources environment.
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