ArticleAnnals of the American Thoracic Society2014
Differential responses to rhinovirus- and influenza-associated pulmonary exacerbations in patients with cystic fibrosis.
Article in Annals of the American Thoracic Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Sweat metabolomics before and after intravenous antibiotics for pulmonary exacerbation in people with cystic fibrosis.Respiratory medicine · 2022Article
- The prevalence of viral infections in children with cystic fibrosis in a tertiary care center in Saudi Arabia.International journal of pediatrics & adolescent medicine · 2020Article
- Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation.Current clinical microbiology reports · 2020Article
- Clinical impact of respiratory virus in pulmonary exacerbations of children with Cystic Fibrosis.PloS one · 2020Article
- Lower Airway Virology in Health and Disease-From Invaders to Symbionts.Medicina (Kaunas, Lithuania) · 2018Review
- A Co-culture Model of PBMC and Stem Cell Derived Human Nasal Epithelium Reveals Rapid Activation of NK and Innate T Cells Upon Influenza A Virus Infection of the Nasal Epithelium.Frontiers in immunology · 2018Article
- Update on Human Rhinovirus and Coronavirus Infections.Seminars in respiratory and critical care medicine · 2016Review
- Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2016Article
- Acute effects of viral respiratory tract infections on sputum bacterial density during CF pulmonary exacerbations.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2015Observational
- Erratum: Differential Responses to Rhinovirus- and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis.Annals of the American Thoracic Society · 2015Article
- Host-microbe interactions in distal airways: relevance to chronic airway diseases.European respiratory review : an official journal of the European Respiratory Society · 2015Review
- Article
Corrections and comments
- Erratum issuedErratum: Differential Responses to Rhinovirus- and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis.2015 · Caverly, Lindsay L [corrected to Caverly, Lindsay J]
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleThe mechanism by which viruses cause exacerbations of chronic airway disease and the capacity of patients with cystic fibrosis (CF) to respond to viral infection are not precisely known.
objectivesTo determine the antiviral response to infection in patients with CF.
methodsSputum was collected from patients with CF with respiratory exacerbation. Viruses were detected in multiplex polymerase chain reaction (PCR)-based assays. Gene expression of 84 antiviral response genes was measured, using a focused quantitative PCR gene array. MEASUREMENTS AND MAIN
resultsWe examined 36 samples from 23 patients with respiratory exacerbation. Fourteen samples tested virus-positive and 22 virus-negative. When we compared exacerbations associated with rhinovirus (RV, n = 9) and influenza (n = 5) with virus-negative specimens, we found distinct patterns of antiviral gene expression. RV was associated with greater than twofold induction of five genes, including those encoding the monocyte-attracting chemokines CXCL10, CXCL11, and CXCL9. Influenza was associated with overexpression of 20 genes, including those encoding the cytokines tumor necrosis factor and IL-12; the kinases MEK, TBK-1, and STAT-1; the apoptosis proteins caspase-8 and caspase-10; the influenza double-stranded RNA receptor RIG-I and its downstream effector MAVS; and pyrin, an IFN-stimulated protein involved in influenza resistance.
conclusionsWe conclude that virus-induced exacerbations of CF are associated with immune responses tailored to specific infections. Influenza induced a more potent response consisting of inflammation, whereas RV infection had a pronounced effect on chemokine expression. As far as we are aware, this study is the first to compare specific responses to different viruses in live patients with chronic airway disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.