ArticleAmerican journal of respiratory cell and molecular biology2014
T cells and lung injury. Impact of rapamycin.
Article in American journal of respiratory cell and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Propolis Alleviates Acute Lung Injury Induced by Heat-Inactivated Methicillin-ResistantNutrients · 2024Article
- Identification of metabolism-related key genes as potential biomarkers for pathogenesis of immune thrombocytopenia.Scientific reports · 2024Article
- Acute inflammation alters lung lymphocytes and potentiates innate-like behavior in young mouse lung CD8 T cells, resembling lung CD8 T cells from old mice.Journal of leukocyte biology · 2023Article
- Update on transfusion-related acute lung injury: an overview of its pathogenesis and management.Frontiers in immunology · 2023Review
- Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-Frontiers in immunology · 2023Article
- Rapamycin ExacerbatesJournal of inflammation research · 2023Article
- Old drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine storm.NPJ systems biology and applications · 2022Article
- The protective effects of bone mesenchymal stem cells on paraquat-induced acute lung injury via the muc5b and ERK/MAPK signaling pathways.American journal of translational research · 2019Article
- Sirolimus alters lung pathology and viral load following influenza A virus infection.Respiratory research · 2017Article
- Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models.Transplant immunology · 2015Article
- Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation.The American journal of pathology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Acute lung injury (ALI) is characterized by pulmonary inflammation and edema. Innate immune cells (e.g., neutrophils and macrophages) are major contributors to inflammation in ALI. Less is known regarding the role of T cells. We examined the effects of rapamycin on inflammation in a LPS-induced murine model of ALI. Rapamycin was administered before and after initiation of injury. Inflammatory parameters, including bronchoalveolar lavage cell counts, T cell surface markers (i.e., cytotoxic T lymphocyte antigen 4 [CTLA4] and fork head-winged helix transcription factor [Foxp3]), T cell activation (CD69), IL-6, and IL-10 were analyzed. Rapamycin significantly decreased inflammatory parameters and decreased Foxp3, CTLA4, and CD69 in CD4(+) T cells. Rapamycin administration before or after the onset of lung injury, as well as systemically or by pulmonary routes, ameliorates inflammation in ALI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.