ArticleJournal of the American Chemical Society2014
Protein-triggered supramolecular disassembly: insights based on variations in ligand location in amphiphilic dendrons.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Stepwise disassembly of supramolecular structures triggered by specific protein binding.Biophysical journal · 2026Article
- Structural Determinants of Stimuli-Responsiveness in Amphiphilic Macromolecular Nano-assemblies.Progress in polymer science · 2024Article
- Supramolecular Self-Associations of Amphiphilic Dendrons and Their Properties.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Article
- Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks.Biomacromolecules · 2021Article
- Using High Molecular Precision to Study Enzymatically Induced Disassembly of Polymeric Nanocarriers: Direct Enzymatic Activation or Equilibrium-Based Degradation?Macromolecules · 2021Review
- Anchoring Supramolecular Polymers to Human Red Blood Cells by Combining Dynamic Covalent and Non-Covalent Chemistries.Angewandte Chemie (International ed. in English) · 2020Article
- Smart Organic Two-Dimensional Materials Based on a Rational Combination of Non-covalent Interactions.Angewandte Chemie (International ed. in English) · 2016Article
- Role of Aromatic Interactions in Temperature-Sensitive Amphiphilic Supramolecular Assemblies.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- A supramolecular dissociation strategy for protein sensing.Chemical communications (Cambridge, England) · 2015Article
- Protein-induced supramolecular disassembly of amphiphilic polypeptide nanoassemblies.Journal of the American Chemical Society · 2015Article
- Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues.Chemical science · 2015Article
- Experimental and theoretical investigations in stimuli responsive dendrimer-based assemblies.Nanoscale · 2015Review
- Consequences of chirality on the dynamics of a water-soluble supramolecular polymer.Nature communications · 2015Article
- Stimuli-responsive nanomaterials for biomedical applications.Journal of the American Chemical Society · 2015Article
- Supramolecular disassembly of facially amphiphilic dendrimer assemblies in response to physical, chemical, and biological stimuli.Accounts of chemical research · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We use monodisperse dendrons that allow control over functional group presentation to investigate the influence of the location of a ligand on protein-induced disassembly and release of encapsulated small molecules. Based on both experiments and molecular dynamics simulations, we demonstrate that ligand location greatly influences release of guest molecules from the dendron-based supramolecular assembly. We show that a ligand moiety grafted to the dendron periphery is more accessible for the target protein in aqueous solution. On the other hand, the ligand moiety placed at the focal point or at the intermediate layer within the dendritic scaffold is less accessible, since it is surrounded by an environment rich in PEG chains, which hinders binding and even influences nonspecific interactions. We also demonstrate that the specific binding between one ligand and the target protein can destabilize the dendritic assembly. Furthermore, if more ligands are available, multivalent interactions are also possible with extravidin, which speed up disassembly and trigger the release of hydrophobic guests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.