ReviewPain management2014
Early repetitive pain in preterm infants in relation to the developing brain.
Review in Pain management, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04092127 (Pain Quantification Study During a Screening for Retinopathy of Premature Babies by RetCam), which is not on this map. Cited by 110 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pain Quantification Study During a Screening for Retinopathy of Premature Babies by RetCam
Who cites it
110 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Long-term alterations in pain sensitivity following preterm birth: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Pooled it
- Clinical rating scales for assessing pain in newborn infants.The Cochrane database of systematic reviews · 2025Pooled it
- Dexmedetomidine for analgesia and sedation in newborn infants receiving mechanical ventilation.The Cochrane database of systematic reviews · 2024Pooled it
- Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates.The Cochrane database of systematic reviews · 2023Pooled it
- Pooled it
- Associations of Mitochondrial Function, Stress, and Neurodevelopmental Outcomes in Early Life: A Systematic Review.Developmental neuroscience · 2022Pooled it
- The effect of facilitated tucking position during painful procedure in pain management of preterm infants in neonatal intensive care unit: a systematic review and meta-analysis.European journal of pediatrics · 2020Pooled it
- Sucrose for analgesia in newborn infants undergoing painful procedures.The Cochrane database of systematic reviews · 2016Pooled it
- Effects of a less invasive suction protocol on pain and physiological stability in preterm infants receiving non-ınvasive ventilation: a randomized controlled trial.BMC pediatrics · 2026Trial
- Multisensory stimulation by mothers: impact on neonatal pain and maternal anxiety during heel blood collection: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2026Trial
- Trial
- Effect of pacifier and pacifier with dextrose in reducing pain during orogastric tube insertion in newborns: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2024Trial
- The role of time interval elimination on pain control of preterm infants by sucrose administration.European journal of clinical pharmacology · 2023Trial
- Article
- Association Between Neonatal Pain Exposure and Neurodevelopmental Outcomes in Very Preterm Infants During the COVID-19 Pandemic: A Retrospective Observational Study.Children (Basel, Switzerland) · 2026Article
- Analgosedation in Neonatal Intensive Care: Current Strategies, Challenges, and Future Perspectives.Life (Basel, Switzerland) · 2026Review
- Radar-Based Monitoring: A Proof of Principle Study in a Piglet Model for a Novel Approach in Non-Contact Vital Sign Monitoring.Sensors (Basel, Switzerland) · 2026Article
- Peripheral venous access in neonates: number of punctures and factors associated with their failure during the first day of life.European journal of pediatrics · 2026Article
- Dexmedetomidine versus opioids for sedation during therapeutic hypothermia in neonatal HIE: efficacy, safety, and dose-response relationship.Pediatric research · 2026Article
- Predicting serum phosphate levels in very preterm infants using machine learning.Frontiers in pediatrics · 2026Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Infants born preterm (<37 weeks of gestation) are particularly vulnerable to procedural stress and pain exposure during neonatal intensive care, at a time of rapid and complex brain development. Concerns regarding effects of neonatal pain on brain development have long been expressed. However, empirical evidence of adverse associations is relatively recent. Thus, many questions remain to be answered. This review discusses the short- and long-term effects of pain-related stress and associated treatments on brain maturation and neurodevelopmental outcomes in children born preterm. The current state of the evidence is presented and future research directions are proposed.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.