ArticleThe British journal of dermatology2014
Factors associated with pruritic papular eruption of human immunodeficiency virus infection in the antiretroviral therapy era.
Article in The British journal of dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 19 citations in OpenAlex.
- Reduced bacterial skin infections in HIV-infected African children randomized to long-term cotrimoxazole prophylaxis.AIDS (London, England) · 2016Trial
- The prevalence and spectrum of mucocutaneous disease in South African people living with HIV and accessing care at a district-level hospital.Southern African journal of HIV medicine · 2020Article
- HIV-Related Skin Disease in the Era of Antiretroviral Therapy: Recognition and Management.American journal of clinical dermatology · 2019Review
- Extremely high HIV-1 viral load in a patient with undiagnosed clinical indicator disease for HIV infection.BMJ case reports · 2015Article
- Thalidomide-A novel therapeutic approach for pruritic papular eruption of HIV.JAAD case reports · 2015Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPruritic papular eruption (PPE) of HIV is common in HIV-infected populations living in the tropics. Its aetiology has been attributed to insect bite reactions and it is reported to improve with antiretroviral therapy (ART). Its presence after at least 6 months of ART has been proposed as one of several markers of treatment failure.
objectivesTo determine factors associated with PPE in HIV-infected persons receiving ART.
methodsA case-control study nested within a 500-person cohort from a teaching hospital in Mbarara, Uganda. Forty-five cases and 90 controls were enrolled. Cases had received ART for ≥ 15 months and had an itchy papular rash for at least 1 month with microscopic correlation by skin biopsy. Each case was individually matched with two controls for age, sex and ART duration.
resultsTwenty-five of 45 cases (56%) had microscopic findings consistent with PPE. At skin examination and biopsy (study enrolment), a similar proportion of PPE cases and matched controls had plasma HIV RNA < 400 copies mL(-1) (96% vs. 85%, P = 0·31). The odds of having PPE increased fourfold with every log increase in viral load at ART initiation (P = 0·02) but not at study enrolment. CD4 counts at ART initiation and study enrolment, and CD4 gains and CD8(+) T-cell activation measured 6 and 12 months after ART commencement were not associated with PPE. Study participants who reported daily insect bites had greater odds of being cases [odds ratio (OR) 8·3, P < 0·001] or PPE cases (OR 8·6, P = 0·01).
conclusionsPruritic papular eruption in HIV-infected persons receiving ART for ≥ 15 months was associated with greater HIV viraemia at ART commencement, independent of CD4 count. Skin biopsies are important to distinguish between PPE and other itchy papular eruptions.
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